Cognitive impairment occurs in a large percent of lupus patients. We have recently shown that a subset of anti-DNA antibodies in patients with SLE binds to a defined linear epitope on the NR2 NMDA receptor. These antibodies can be found in the cerebrospinal fluid (CSF) as well as in serum. We initially, proposed to explore further the antigenicity of the NR2 receptor in SLE and the functional consequence,' of anti-receptor antibodies in a mouse model of disease. We have now acquired sufficient data from murine studies to show that cognitive impairment can be mediated by these antibodies and is associated with alterations in magnetic resonance spectroscopy. We, therefore, propose a new aim to this study: to determine if there is an association of anti-NR2 antibody, abnormal magnetic resonance spectroscopy and impaired cognitive function in a cohort of 30 SLE patients. In a longitudinal study, we will evaluate whether changes in cognitive performance are accompanied spectroscopic changes. The overall goal of this pilot study is to generate the data to design a definitive study. Ultimately, we hope to develop the scientific foundation for a clinical trial of NR2 receptor antagonists to protect against cognitive decline in SLE. ? ?
| Son, Myoungsun; Diamond, Betty (2015) C1q-mediated repression of human monocytes is regulated by leukocyte-associated Ig-like receptor 1 (LAIR-1). Mol Med 20:559-68 |
| Son, Myoungsun; Santiago-Schwarz, Frances; Al-Abed, Yousef et al. (2012) C1q limits dendritic cell differentiation and activation by engaging LAIR-1. Proc Natl Acad Sci U S A 109:E3160-7 |
| Wang, Ying-Hua; Yan, Yi; Rice, Jeffrey S et al. (2011) Enforced expression of the apoptosis inhibitor Bcl-2 ablates tolerance induction in DNA-reactive B cells through a novel mechanism. J Autoimmun 37:18-27 |
| Cohen-Solal, Joel; Diamond, Betty (2011) Lessons from an anti-DNA autoantibody. Mol Immunol 48:1328-31 |
| Bloom, Ona; Cheng, Kai Fan; Cheng, Kai Fen et al. (2011) Generation of a unique small molecule peptidomimetic that neutralizes lupus autoantibody activity. Proc Natl Acad Sci U S A 108:10255-9 |
| Yildirim-Toruner, Cagri; Diamond, Betty (2011) Current and novel therapeutics in the treatment of systemic lupus erythematosus. J Allergy Clin Immunol 127:303-12; quiz 313-4 |
| Diamond, Betty; Tracey, Kevin J (2011) Mapping the immunological homunculus. Proc Natl Acad Sci U S A 108:3461-2 |
| Diamond, B; Bloom, O; Al Abed, Y et al. (2011) Moving towards a cure: blocking pathogenic antibodies in systemic lupus erythematosus. J Intern Med 269:36-44 |
| Aranow, Cynthia; Diamond, Betty; Mackay, Meggan (2010) Glutamate receptor biology and its clinical significance in neuropsychiatric systemic lupus erythematosus. Rheum Dis Clin North Am 36:187-201, x-xi |
| Peled, Jonathan U; Yu, J Jessica; Venkatesh, Jeganathan et al. (2010) Requirement for cyclin D3 in germinal center formation and function. Cell Res 20:631-46 |
Showing the most recent 10 out of 17 publications
