Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR049217-02
Application #
6694428
Study Section
Immunological Sciences Study Section (IMS)
Program Officer
Gretz, Elizabeth
Project Start
2003-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$275,533
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Scatizzi, John C; Hutcheson, Jack; Pope, Richard M et al. (2010) Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis Rheum 62:441-51
Gierut, Angelica; Perlman, Harris; Pope, Richard M (2010) Innate immunity and rheumatoid arthritis. Rheum Dis Clin North Am 36:271-96
Scatizzi, John C; Mavers, Melissa; Hutcheson, Jack et al. (2009) The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages. Eur J Immunol 39:820-5
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Tran, Tri M; Temkin, Vladislav; Shi, Bo et al. (2009) TNFalpha-induced macrophage death via caspase-dependent and independent pathways. Apoptosis 14:320-32
Liu, Hongtao; Shi, Bo; Huang, Chiang-Ching et al. (2008) Transcriptional diversity during monocyte to macrophage differentiation. Immunol Lett 117:70-80
Shahrara, Shiva; Huang, Qiquan; Mandelin 2nd, Arthur M et al. (2008) TH-17 cells in rheumatoid arthritis. Arthritis Res Ther 10:R93
Huang, Qi-Quan; Hossain, M Moazzem; Wu, Kaichun et al. (2008) Role of H2-calponin in regulating macrophage motility and phagocytosis. J Biol Chem 283:25887-99
Shahrara, Shiva; Proudfoot, Amanda E I; Park, Christy C et al. (2008) Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritis. J Immunol 180:3447-56
Pope, Richard M; Tschopp, Jurg (2007) The role of interleukin-1 and the inflammasome in gout: implications for therapy. Arthritis Rheum 56:3183-8

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