This application is in response to the Program Announcement """"""""Women's Health in Sports and Exercise (PA-02-115),"""""""" and the goal of the proposed work is to determine the incidence and predictors of musculoskeletal injuries in a cohort of free-living adult women. There are approximately 40-50 million sedentary adults in the U.S. at present, and public health and medical authorities recommend that these persons accumulate at least 30 minutes of moderate intensity physical activity per day. The most prevalent risk associated with physical activity is musculoskeletal injury, with an incidence of activity-related injury as high as 25% per year in community dwelling adults. Women athletes suffer higher rates of injury than their male counterparts, but there is insufficient information available on injury incidence in representative population samples of free-living individuals, especially in women. Biomechanical and orthopedic factors such as excessive Q-angle or foot pronation are plausible putative risk factors for activity-related injury in women athletes;however, empirical evidence of these associations is lacking in non-competitive physical activity settings. The public health burden of physical activity-related injuries that might ensue if all sedentary women began to exercise at recommended levels is currently unknown. The focus in the proposed prospective observational study will be on quantifying the public health burden of physical activity related injuries, and to identify demographic, orthopedic, biomechanical, body habitus, and physical activity- related risk factors for musculoskeletal injury. Strengths of the study will be the recruitment of a population of 885 women broadly representative of the community, an extensive baseline clinical assessment of possible risk predictors, ongoing surveillance of both physical activity habits and injury outcomes, confirmation of injury events by medical record review, and calculation of injury-related costs. We will collect information pertaining to sedentary, moderate, and vigorous physical activity behaviors that might be effect modifiers or confounding factors of the association between the emerging risk predictors and injury risk. Findings from this study will provide empirical evidence upon which strategies for injury prevention can be developed and current health-related activity recommendations can be refined to minimize the risk of injury among susceptible women who are physically active.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Research Project (R01)
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Study Section
Psychosocial Risk and Disease Prevention Study Section (PRDP)
Program Officer
Panagis, James S
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Cooper Institute
United States
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Kim, Youngdeok; Kang, Minsoo; Tacón, Anna M et al. (2016) Longitudinal trajectories of physical activity in women using latent class growth analysis: The WIN Study. J Sport Health Sci 5:410-416
Kaplan, Robert M; Herrmann, Alison K; Morrison, James T et al. (2014) Costs associated with women's physical activity musculoskeletal injuries: the women's injury study. J Phys Act Health 11:1149-55
Trudelle-Jackson, Elaine; Leonard, David; Morrow Jr, James R (2014) Musculoskeletal risk factors as predictors of injury in community-dwelling women. Med Sci Sports Exerc 46:1752-7
Howard, Erica N; DeFina, Laura F; Leonard, David et al. (2013) Physical activity and musculoskeletal injuries in women: the Women's Injury Study. J Womens Health (Larchmt) 22:1038-42
Vingren, Jakob L; Morrow Jr, James R; Trudelle-Jackson, Elaine et al. (2013) Prevalence of muscle-strengthening activities in women: the WIN study. J Phys Act Health 10:1008-15
Morrow Jr, James R; Defina, Laura F; Leonard, David et al. (2012) Meeting physical activity guidelines and musculoskeletal injury: the WIN study. Med Sci Sports Exerc 44:1986-92
Frierson, Georita M; Morrow Jr, James R; Vidales, Andrew (2012) Successful minority recruitment and adherence in physical activity Internet-based research: the WIN study. J Natl Med Assoc 104:544-54
Trudelle-Jackson, Elaine; Jackson, Allen W; Morrow Jr, James R (2011) Relations of meeting national public health recommendations for muscular strengthening activities with strength, body composition, and obesity: the Women's Injury Study. Am J Public Health 101:1930-5
Mathew, Merly; Morrow, James R; Frierson, Georita M et al. (2011) Assessing digital literacy in web-based physical activity surveillance: the WIN study. Am J Health Promot 26:90-5
Morrow Jr, James R; Bain, Tyson M; Frierson, Georita M et al. (2011) Long-term tracking of physical activity behaviors in women: the WIN Study. Med Sci Sports Exerc 43:165-70

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