The anatomic and biomechanical properties of peri-articular bone play a primary role in the dispersion of loading forces across the joint. Indeed, 30-50% of a load across a knee is absorbed by peri-articular bone compared to only 1-3% by articular cartilage. The attenuation of loading forces by peri-articular bone is critical in protecting articular cartilage from damage. However, thickening of subchondral bone and disruption of peri-articular trabecular architecture occur early in osteoarthritis (OA), and may even antedate cartilage damage. These changes, together with the later development of gross pathological disruption of subchondral bone by 'cysts', attrition and trabecular collapse (common in OA), are likely to impair the capability of peri-articular bone to attenuate compressive forces and further predispose to progression. Clinical studies provide further evidence that pathological processes in peri-articular bone influence the course of OA. OA knees with abnormal peri-articular scintigraphic appearances, or subchondral bone marrow lesions on MRI, have greater risk for progression. Measures of systemic bone health such as bone density (BMD) and vitamin D also strongly influence the risk of OA progression. This suggests that the nature of the peri-articular bone response in OA predicates stabilization or progression, and that this may be influenced by systemic bone factors such as BMD and vitamin D. These observations compel us to study the longitudinal role of peri-articular bone in OA to increase understanding of the mechanisms of progression, refine predictive models, and suggest tissue-targeted interventions. Technical modifications to dual x-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) protocols offer appealing approaches to measurement of BMD and trabecular morphology of peri-articular bone. The Osteoarthritis Initiative (OAI) cohort provides an unequalled opportunity to study the role of peri- articular and systemic bone factors in the progression of knee OA in a large sample whose comprehensive evaluations include annual measurement of cartilage volume by 3-Tesla MRI. The proposed ancillary study would be deployed in the progression subcohort and would add longitudinal DXA BMD measurement of both knees and right femoral neck, knee peri-articular trabecular morphometry using high-resolution MRI, bone marrow lesion, cyst and meniscal damage scores, serum 25-hydroxy vitamin D, parathormone (PTH), and vitamin D receptor genotyping. All these data will join and enrich the OAI public data set at specified time points.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR054938-04
Application #
7845517
Study Section
Special Emphasis Panel (ZRG1-MOSS-L (05))
Program Officer
Lester, Gayle E
Project Start
2007-06-11
Project End
2012-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
4
Fiscal Year
2010
Total Cost
$674,043
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
079532263
City
Boston
State
MA
Country
United States
Zip Code
02111
Lo, Grace H; Schneider, Erika; Driban, Jeffrey B et al. (2018) Periarticular bone predicts knee osteoarthritis progression: Data from the Osteoarthritis Initiative. Semin Arthritis Rheum 48:155-161
MacKay, James W; Kapoor, Geeta; Driban, Jeffrey B et al. (2018) Association of subchondral bone texture on magnetic resonance imaging with radiographic knee osteoarthritis progression: data from the Osteoarthritis Initiative Bone Ancillary Study. Eur Radiol 28:4687-4695
Son, Min-Sun; Levenston, Marc E (2017) Quantitative tracking of passage and 3D culture effects on chondrocyte and fibrochondrocyte gene expression. J Tissue Eng Regen Med 11:1185-1194
Antony, B; Driban, J B; Price, L L et al. (2017) The relationship between meniscal pathology and osteoarthritis depends on the type of meniscal damage visible on magnetic resonance images: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage 25:76-84
Pang, Jincheng; Driban, Jeffrey B; McAlindon, Timothy E et al. (2015) On the use of coupled shape priors for segmentation of magnetic resonance images of the knee. IEEE J Biomed Health Inform 19:1153-67
Zhang, Ming; Driban, Jeffrey B; Price, Lori Lyn et al. (2014) Development of a rapid knee cartilage damage quantification method using magnetic resonance images. BMC Musculoskelet Disord 15:264
Driban, Jeffrey B; Barbe, Mary F; Amin, Mamta et al. (2014) Validation of quantitative magnetic resonance imaging-based apparent bone volume fraction in peri-articular tibial bone of cadaveric knees. BMC Musculoskelet Disord 15:143
Zhang, Fang Fang; Driban, Jeffrey B; Lo, Grace H et al. (2014) Vitamin D deficiency is associated with progression of knee osteoarthritis. J Nutr 144:2002-8
Pang, Jincheng; Driban, Jeffrey B; Destenaves, Geoffroy et al. (2013) Quantification of bone marrow lesion volume and volume change using semi-automated segmentation: data from the osteoarthritis initiative. BMC Musculoskelet Disord 14:3
Driban, Jeffrey B; Lo, Grace H; Price, Lori et al. (2013) Bone marrow lesion volume reduction is not associated with improvement of other periarticular bone measures: data from the Osteoarthritis Initiative. Arthritis Res Ther 15:R153

Showing the most recent 10 out of 14 publications