Osteoarthritis (OA) is a leading cause of functional disability in the United States and worldwide. Premature development of knee OA is recognized with increasing frequency in young adults after anterior cruciate ligament (ACL) reconstruction (ACLR). As early as 7 to 15 years following reconstruction, a large majority of individuals develop knee OA, a major cause of pain, functional disability and decline in quality of life throughout the adult life-span. In line with the mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases, this proposal will advance knowledge into the causes, treatment, and prevention of knee OA and related disability after ACLR. The long-term objective of our team is to improve the current model of care for patients after ACLR. This prospective study will provide critical data needed to inform an effective future clinical trial. The proposed Aims incorporate multimodal testing of outcomes following ACLR. Through the proposed aims, we will obtain critical knowledge to guide our future clinical trial.

Public Health Relevance

/PUBLIC HEALTH RELEVANCE STATEMENT Osteoarthritis (OA) is a leading cause of functional disability in the United States and worldwide. Premature development of knee OA is recognized with increasing frequency in young adults after anterior cruciate ligament (ACL) reconstruction (ACLR). The long-term objective of our team is to improve the current model of care for patients after ACLR. This prospective study will provide critical data needed to inform an effective future clinical trial.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR070486-01A1
Application #
9308429
Study Section
Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Review Committee (AMSC)
Program Officer
Lester, Gayle E
Project Start
2017-06-01
Project End
2020-05-31
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
1
Fiscal Year
2017
Total Cost
$158,085
Indirect Cost
$48,085
Name
Ohio State University
Department
Other Health Professions
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210