Despite the considerable mass appeal of popular diet books, such approaches lack data to support their efficacy and safety. Despite its widespread use for more than 30 years, the Atkins diet has never been evaluated in a large randomized controlled trial (RCT). Data from large RCTs are necessary to help physicians, patients and the broader health care community make informed decisions about the safety and efficacy of these programs. The current proposal will assess the short-term and long-term clinical effects of the Atkins diet in 360 obese men and women. Participants will be randomized to the Atkins diet (low-carbohydrate, unlimited fat and protein) or a conventional USDA diet (high-carbohydrate, low-fat). The effects of each dietary approach on changes in: 1) weight and body composition; 2) metabolic and organ function; and 3) exercise tolerance will be evaluated.
| Makris, A; Darcey, V L; Rosenbaum, D L et al. (2013) Similar effects on cognitive performance during high- and low-carbohydrate obesity treatment. Nutr Diabetes 3:e89 |
| Mohler 3rd, Emile R; Sibley, Alexandra A; Stein, Richard et al. (2013) Endothelial function and weight loss: comparison of low-carbohydrate and low-fat diets. Obesity (Silver Spring) 21:504-9 |
| Friedman, Allon N; Ogden, Lorraine G; Foster, Gary D et al. (2012) Comparative effects of low-carbohydrate high-protein versus low-fat diets on the kidney. Clin J Am Soc Nephrol 7:1103-11 |
| Borradaile, Kelley E; Halpern, Scott D; Wyatt, Holly R et al. (2012) Relationship between treatment preference and weight loss in the context of a randomized controlled trial. Obesity (Silver Spring) 20:1218-22 |
| Makris, Angela; Foster, Gary D (2011) Dietary approaches to the treatment of obesity. Psychiatr Clin North Am 34:813-27 |
| Martin, Corby K; Rosenbaum, Diane; Han, Hongmei et al. (2011) Change in food cravings, food preferences, and appetite during a low-carbohydrate and low-fat diet. Obesity (Silver Spring) 19:1963-70 |
| Foster, Gary D; Wyatt, Holly R; Hill, James O et al. (2010) Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. Ann Intern Med 153:147-57 |
| de las Fuentes, Lisa; Waggoner, Alan D; Mohammed, B Selma et al. (2009) Effect of moderate diet-induced weight loss and weight regain on cardiovascular structure and function. J Am Coll Cardiol 54:2376-81 |
| Foster, Gary D; Makris, Angela P; Bailer, Brooke A (2005) Behavioral treatment of obesity. Am J Clin Nutr 82:230S-235S |
| Foster, Gary D; Wyatt, Holly R; Hill, James O et al. (2003) A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med 348:2082-90 |
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