Abstract

Grant number: 1 R01 AT008754-01 PI Name: Weaver, Connie M. Modified Project Summary/Abstract Section Polyphenolic-rich plant sources, including berries, reduce age-relate bone loss. Estrogen loss at menopause and during aging leads to accumulation of reactive oxidant species (ROS). Ubiquitinization and degradation of the transcription factor Nrf2 is impeded by oxidative stress allowing Nrf2 to activate antioxidant response elements in target genes to express proteins that detoxify ROS. We will test our hypothesis that bioactive polyphenol metabolites from Vaccinium berries work through this mechanism to reduce bone loss through two specific aims.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Project (R01)
Project #
5R01AT008754-04
Application #
9331437
Study Section
Special Emphasis Panel (ZAT1)
Program Officer
Weber, Wendy J
Project Start
2014-09-30
Project End
2019-08-31
Budget Start
2017-09-01
Budget End
2018-08-31
Support Year
4
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Nutrition
Type
Schools of Public Health
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907