Abstract

The overall objective of the proposed research is to understand the pathogenesis and immunologic features of Marek's disease (MD) in chickens. Specific objectives include: 1) determining the relationship between genetic susceptibility and activation of T-cells as the mechanism providing transformable target cells, 2) investigation of factors, e.g. immune responses, which influence the development and maintenance of latency with MD virus, 3) characterization of molecular biological aspects of oncogenic and nononcogenic MD viruses and various virus-host cell interrelationships and 4) further characterization of immunological effector systems and target antigens important in resistance and vaccinal immunity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA006709-26
Application #
3163249
Study Section
Virology Study Section (VR)
Project Start
1975-09-01
Project End
1991-02-28
Budget Start
1988-03-01
Budget End
1989-02-28
Support Year
26
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Cornell University
Department
Type
Schools of Veterinary Medicine
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850

  Publications

Pratt, W D; Morgan, R; Schat, K A (1992) Cell-mediated cytolysis of lymphoblastoid cells expressing Marek's disease virus-specific phosphorylated polypeptides. Vet Microbiol 33:93-9
Schat, K A; Pratt, W D; Morgan, R et al. (1992) Stable transfection of reticuloendotheliosis virus-transformed lymphoblastoid cell lines. Avian Dis 36:432-9
Schat, K A; Chen, C L; Calnek, B W et al. (1991) Transformation of T-lymphocyte subsets by Marek's disease herpesvirus. J Virol 65:1408-13
Calnek, B W; Schat, K A (1991) Proliferation of chicken lymphoblastoid cells after in vitro infection with Marek's disease virus. Avian Dis 35:728-37
Schat, K A (1991) Importance of cell-mediated immunity in Marek's disease and other viral tumor diseases. Poult Sci 70:1165-75
Calnek, B W; Lucio, B; Schat, K A et al. (1989) Pathogenesis of Marek's disease virus-induced local lesions. 1. Lesion characterization and cell line establishment. Avian Dis 33:291-302
Weinstock, D; Schat, K A; Calnek, B W (1989) Cytotoxic T lymphocytes in reticuloendotheliosis virus-infected chickens. Eur J Immunol 19:267-72
Calnek, B W; Adene, D F; Schat, K A et al. (1989) Immune response versus susceptibility to Marek's disease. Poult Sci 68:17-26
Lillehoj, H S; Lillehoj, E P; Weinstock, D et al. (1988) Functional and biochemical characterizations of avian T lymphocyte antigens identified by monoclonal antibodies. Eur J Immunol 18:2059-65
Buscaglia, C; Calnek, B W; Schat, K A (1988) Effect of immunocompetence on the establishment and maintenance of latency with Marek's disease herpesvirus. J Gen Virol 69 ( Pt 5):1067-77

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