Avian defective leukemia viruses (DLV) have been useful in defining some of the mechanisms in viral oncogenesis. Our laboratory has been extensively engaged in the study of different strains of acute leukemia viruses and their interaction with avian hemopoiesis. Our goal is to continue the systematic characterization of the target cell for avian retroviruses and its relationship with cellular differentiation. We have described the interesting findings of spontaneous differentiation of leukemic cells after infection of embryonic cells with avian erythroblastosis virus (AEV). This proposal will include a detailed analysis of the nature of the embryonic target cell and the type of hemoglobin expressed before and after differentiation. A mast-like cell has been isolated from leukemic Japanese quail infected with AEV. A careful study will be directed to the important question of how erythroblastosis virus induces a different type of leukemia in another host. Moreover, this proposal will attempt to examine whether different lineages are involved in the leukemic process.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA010697-21
Application #
3163378
Study Section
Virology Study Section (VR)
Project Start
1976-01-01
Project End
1989-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
21
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Florida
Department
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611