Abstract

The observed marked improvement in efficacy of hyperbaric oxygen (O2 3ATA) by pentobarbital anesthesia to increase the response of C3H mammary carcinoma to irradiation will be evaluated using a series of spontaneous tumors (importance of histology, tumor size, anesthetic agent, depth of anesthesia, fractionation pattern, body temperature, blood perfusion of tumor, etc.) The potential of combining chemical sensitizers of hypoxic cells with hyperbaric oxygen to improve results of radiation therapy will be investigated in murine tumors; the two sensitizers will be combined at dose or PO2 levels which independently have comparable enhancement ratios. A """"""""head on"""""""" comparison of the Therapeutic Gain Factors for photons plus O2 3ATA, photons plus misonidazole, and fast neutrons using a spectrum of spontaneous tumors of the C3Hf/Sed mouse is to be performed. The phenomenon of heat induced thermal tolerance will be studied to determine its time course, magnitude, dependence upon severity of the inducing heat treatment, time between the two exposures. Biological characterization of 9 spontaneous tumors is to be completed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA013311-14
Application #
3163743
Study Section
Radiation Study Section (RAD)
Project Start
1975-10-01
Project End
1985-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
14
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Shan, Weiwei; Liu, Jinsong (2009) Inflammation: a hidden path to breaking the spell of ovarian cancer. Cell Cycle 8:3107-11
Kozin, Sergey V; Niemierko, Andrzej; Huang, Peigen et al. (2008) Inter- and intramouse heterogeneity of radiation response for a growing paired organ. Radiat Res 170:264-7
Pardo, F S; Hsu, D W; Zeheb, R et al. (2004) Mutant, wild type, or overall p53 expression: freedom from clinical progression in tumours of astrocytic lineage. Br J Cancer 91:1678-86
Kozin, S V; Shkarin, P; Gerweck, L E (2001) The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics. Cancer Res 61:4740-3
Chastagner, P; Kozin, S V; Taghian, A (2001) Topotecan selectively enhances the radioresponse of human small-cell lung carcinoma and glioblastoma multiforme xenografts in nude mice. Int J Radiat Oncol Biol Phys 50:777-82
Griffon-Etienne, G; Boucher, Y; Brekken, C et al. (1999) Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Res 59:3776-82
Budach, W; Gioioso, D; Taghian, A et al. (1997) Repopulation capacity during fractionated irradiation of squamous cell carcinomas and glioblastomas in vitro. Int J Radiat Oncol Biol Phys 39:743-50
Griffon-Etienne, G; Boucher, Y; Jain, R K et al. (1997) Effects of needle insertion in tumors on interstitial fluid pressure. Microvasc Res 54:174-7
Huang, P; Taghian, A; Hsu, D W et al. (1996) Spontaneous metastasis, proliferation characteristics and radiation sensitivity of fractionated irradiation recurrent and unirradiated human xenografts. Radiother Oncol 41:73-81
Huang, P; Taghian, A; Allam, A et al. (1996) The effect of whole-body irradiation of nude mice on the tumor transplantability and control probability of a human soft tissue sarcoma xenograft. Radiat Res 145:337-42

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