A long-term study directed at the isolation, characterization and structural elucidation of new and potentially useful cancer chemotherapeutic drugs from marine animals has been proposed. Support would be used to isolate and characterize anti-cancer agents from confirmed active extracts of marine invertebrates, and marine vertebrates. Maximum effort would be devoted to marine animal species affording extracts with outstanding confirmed level activity (T/C greater than 150) in the National Cancer Institute's murine PS lymphocytic leukemia screening system. As each problem is solved (or placed in a lower priority due to decreasing or lost activity during fractionation guided by bioassay) it would be replaced by another (of high priority) from a current collection of over 300 marine animal specied giving extracts with a confirmed level of activity. The lower animals represent an exceedingly productive source of new cancer chemotherapeutic drugs and all effort will be directed at making such new substances available to the Division of Cancer Treatment, National Cancer Institute.

National Institute of Health (NIH)
National Cancer Institute (NCI)
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Bio-Organic and Natural Products Chemistry Study Section (BNP)
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Arizona State University-Tempe Campus
Schools of Arts and Sciences
United States
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Pettit, George R; Meng, Yanhui; Gearing, R Patrick et al. (2004) Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives). J Nat Prod 67:214-20
Pettit, G R; Numata, A; Cragg, G M et al. (2000) Isolation and structures of schleicherastatins 1-7 and schleicheols 1 and 2 from the teak forest medicinal tree Schleichera oleosa. J Nat Prod 63:72-8
Pettit, G R; McNulty, J; Herald, D L et al. (1997) Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana. J Nat Prod 60:180-3
McBain, J A; Eastman, A; Simmons, D L et al. (1996) Phorbol ester augments butyrate-induced apoptosis of colon cancer cells. Int J Cancer 67:715-23
Pettit, G R; Singh, S B; Boyd, M R et al. (1995) Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5, and A-6(1a) J Med Chem 38:1666-72
Pettit, G R; Freeman, S; Simpson, M J et al. (1995) Antineoplastic agents 320: synthesis of a practical pancratistatin prodrug. Anticancer Drug Des 10:243-50
Pettit, G R; Pettit 3rd, G R; Backhaus, R A et al. (1995) Antineoplastic agents, 294. Variations in the formation of pancratistatin and related isocarbostyrils in Hymenocallis littoralis. J Nat Prod 58:37-43
Pettit, G R; Pettit 3rd, G R; Groszek, G et al. (1995) Antineoplastic agents, 301. An investigation of the Amaryllidaceae genus Hymenocallis. J Nat Prod 58:756-9
Pettit, G R; Xu, J P; Williams, M D et al. (1994) Isolation and structure of cephalostatins 10 and 11. J Nat Prod 57:52-63
Stanwell, C; Gescher, A; Bradshaw, T D et al. (1994) The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells. Int J Cancer 56:585-92

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