Water makes up from 75 to 85% of all living matter. Thus water is not only the medium in which all biomedical reactions take place, it is also by far the major substance of living matter. For these fundamental reasons, the discovery that water in cancer cells has longer NMR relaxation time (T1 and T2) is of great potential importance. Having established that these longer T1 and T2 are not due to the larger water contents but are distinctly different from all normal host animal tissues but are very similar among all variety of cancer cells of diverse origin, our immediate plan for the next year would encompass both fundamental inquiries of the physico-chemical basis for differences in T1 and T2 of model systems as well as living cells. We will also continue our investigation of the different T1 and T2 of host tissues from cancer-bearing animals particularly in relation to animals bearing """"""""red ascites"""""""" and bearing """"""""yellow ascites"""""""" with the hope of understanding more about the process of cancer cell dissemination.

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National Cancer Institute (NCI)
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Pennsylvania Hospital (Philadelphia)
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Ling, G N; Ochsenfeld, M M (1991) The majority of potassium ions in muscle cells is adsorbed on beta- and gamma-carboxyl groups of myosin: potassium-ion-adsorbing carboxyl groups on myosin heads engage in cross-bridge formation during contraction. Physiol Chem Phys Med NMR 23:133-60
Ling, G N; Kolebic, T; Damadian, R (1990) Low paramagnetic-ion content in cancer cells: its significance in cancer detection by magnetic resonance imaging. Physiol Chem Phys Med NMR 22:1-14
Ling, G N; Ochsenfeld, M M (1989) The physical state of water in living cells and model systems. XII. The influence of the conformation of a protein on the solubility of Na+ (sulfate), sucrose, glycine and urea in the water in which the protein is also dissolved. Physiol Chem Phys Med NMR 21:19-44
Ling, G N (1989) Partial preservation of the ability of accumulating alkali-metal ions in 2 mm muscle cell segments with both ends open. Physiol Chem Phys Med NMR 21:13-4
Ling, G N (1988) Solute exclusion by polymer and protein-dominated water: correlation with results of nuclear magnetic resonance (NMR) and calorimetric studies and their significance for the understanding of the physical state of water in living cells. Scanning Microsc 2:871-84
Ling, G N (1988) A physical theory of the living state: application to water and solute distribution. Scanning Microsc 2:899-913
Ling, G N; Hu, W (1988) Studies on the physical state of water in living cells and model systems. X. The dependence of the equilibrium distribution coefficient of a solute in polarized water on the molecular weights of the solute: experimental confirmation of the ""size rule"" i Physiol Chem Phys Med NMR 20:293-307
Ling, G N; Ochsenfeld, M M (1988) Studies on the physical state of water in living cells and model systems. XI. The equilibrium distribution coefficients of pentoses in muscle cell water: their dependence primarily on the molecular weights of the pentoses and lesser dependence on their st Physiol Chem Phys Med NMR 20:309-17
Ling, G N; Fu, Y Z (1988) An electronic mechanism in the action of drugs, ATP, transmitters and other cardinal adsorbents. II. Effect of ouabain on the relative affinities for Li+, Na+, K+, and Rb+ of surface anionic sites that mediate the entry of Cs+ into frog ovarian eggs. Physiol Chem Phys Med NMR 20:61-77
Ling, G N (1987) On the large error introduced in the estimate of the density of membrane pores from permeability measurements when diffusion in ""unstirred layer"" within the cells is disregarded. Physiol Chem Phys Med NMR 19:199-207

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