Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA016669-21
Application #
2086511
Study Section
Special Emphasis Panel (ZRG2-MEP (02))
Project Start
1978-08-01
Project End
1999-06-30
Budget Start
1996-07-15
Budget End
1997-06-30
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
New York University
Department
Pathology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
Ocampo, Maria T A; Chaung, Wenren; Marenstein, Dina R et al. (2002) Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity. Mol Cell Biol 22:6111-21
Boorstein, R J; Cummings Jr, A; Marenstein, D R et al. (2001) Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1. J Biol Chem 276:41991-7
Marenstein, D R; Ocampo, M T; Chan, M K et al. (2001) Stimulation of human endonuclease III by Y box-binding protein 1 (DNA-binding protein B). Interaction between a base excision repair enzyme and a transcription factor. J Biol Chem 276:21242-9
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Hilbert, T P; Chaung, W; Boorstein, R J et al. (1997) Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III. J Biol Chem 272:6733-40
Hilbert, T P; Boorstein, R J; Kung, H C et al. (1996) Purification of a mammalian homologue of Escherichia coli endonuclease III: identification of a bovine pyrimidine hydrate-thymine glycol DNAse/AP lyase by irreversible cross linking to a thymine glycol-containing oligoxynucleotide. Biochemistry 35:2505-11
Zuo, S; Boorstein, R J; Cunningham, R P et al. (1995) Comparison of the effects of UV irradiation on 5-methyl-substituted and unsubstituted pyrimidines in alternating pyrimidine-purine sequences in DNA. Biochemistry 34:11582-90
Zuo, S; Boorstein, R J; Teebor, G W (1995) Oxidative damage to 5-methylcytosine in DNA. Nucleic Acids Res 23:3239-43
O'Donnell, R E; Boorstein, R J; Cunningham, R P et al. (1994) Effect of pH and temperature on the stability of UV-induced repairable pyrimidine hydrates in DNA. Biochemistry 33:9875-80
Lustig, M J; Cadet, J; Boorstein, R J et al. (1992) Synthesis of the diastereomers of thymidine glycol, determination of concentrations and rates of interconversion of their cis-trans epimers at equilibrium and demonstration of differential alkali lability within DNA. Nucleic Acids Res 20:4839-45

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