The aim of this project is to identify and analyze in detail the cell-surface binding sites (""""""""receptors"""""""") for fibronectin and other extracellular matrix molecules. These receptors will be studied in fibroblasts and platelets. Biochemical, cell biological and molecular biological techniques, including cloning of cDNAs for the receptor proteins, will be used to elucidate the structure and function of these receptors and determine whether they constitute transmembrane connections between the extracellular matrix and the cytoskeleton. Potential changes during oncogenic transformation, platelet activation and embryological development will be analyzed. The role of extracellular matrix in the control of cell migration will be investigated. This work should provide information relevant to the understanding of cell adhesion and migration and the role which these processes play in malignancy, hemostasis, thrombosis and embryological development.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA017007-13
Application #
3164591
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1977-05-01
Project End
1990-11-30
Budget Start
1987-12-01
Budget End
1988-11-30
Support Year
13
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Roper, Jatin; Tammela, Tuomas; Cetinbas, Naniye Malli et al. (2017) In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat Biotechnol 35:569-576
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Wong, Sunny Y; Crowley, Denise; Bronson, Roderick T et al. (2008) Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer. Clin Exp Metastasis 25:109-18
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Xu, Lei; Hynes, Richard O (2007) GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle 6:160-5
Wong, Sunny Y; Hynes, Richard O (2006) Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide? Cell Cycle 5:812-7

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