The objectives of this grant are: to establish the usefulness of tissue DHT concentrations in prostate cancer tissue for the prediction of the occurrence and duration of clinical response to hormonal or ablative therapy in advanced prostate cancer. This will be supplemented by attempting to establish biochemical parameters to identify the nonhormone dependent clone present in prostate cancer by measuring PAP/DHT ratios, which appear to be a potential marker for such clones. A possible relationship between tissue grading alone or combined with biochemical parameters to further help in the prediction of clinical response to hormonal therapy will also be studied. A possible role for adrenal cortical androgens in producing relapse in hormone treated patients will be assessed by the simultaneous measurement of plasma testosterone levels and tissue DHT levels at the time of relapse. The prediction of the long term outlook in patients with less advanced disease who are radiated will also be studied by electron and light microscopy, tissue culture techniques and measurement of DHT concentrations 1 to 1 1/2 years following radiation therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA018003-11
Application #
3164824
Study Section
Pathology B Study Section (PTHB)
Project Start
1978-06-01
Project End
1987-05-31
Budget Start
1986-06-01
Budget End
1987-05-31
Support Year
11
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Mercy Hospital and Medical Center (San Diego)
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92103