Abstract

This project involves the study of erythropoietin-responsive cells, cells that respond to colonystimulating factor, pluripotent hematopoietic stem cells, and the interrelationships among them. Our working hypothesis is that these are essentially the same cells and can be defined by the presence or absence of receptors for the inducers of hematopoietic cell differentiation. We are studying the properties of the erythropoietin receptor of mouse cells and the role of interleukin-3 on the regulation of response to erythropoietin. (M)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA018375-12
Application #
3164934
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1978-07-01
Project End
1988-04-30
Budget Start
1986-05-01
Budget End
1987-04-30
Support Year
12
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Nijhof, W; Wierenga, P K; Sahr, K et al. (1987) Induction of globin mRNA transcription by erythropoietin in differentiating erythroid precursor cells. Exp Hematol 15:779-84
Weiss, T L; Kung, C K; Goldwasser, E (1985) The frequency of bone marrow cells that bind erythropoietin. J Cell Biochem 27:57-65
Choppin, J; Casadevall, N; Lacombe, C et al. (1985) Production of erythropoietin by cloned malignant murine erythroid cells. Exp Hematol 13:610-5
Goldwasser, E (1985) The action of erythropoietin as the inducer of erythroid differentiation. Prog Clin Biol Res 184:77-84