The search for new and effective treatments for the group of diseases known collectively as cancer continues to be a highly significant research goal. In continuance of a highly productive research program aimed at the several aspects of the development of new potential anticancer agents a multidisciplinary program is proposed.
The specific aims of the proposed research are: i) Daphnopsis sellowiana, Gelsemium elegans, Catharanthus roseus, and Camptotheca acuminata, ii) determination of the structure of the biologically active compounds isolated using both spectroscopic and chemical interconversion techniques, iii) structure modification and/or synthesis of new and selected known compounds with a view to establishing unambiguous spectroscopic properties, enhancing activity and/or understanding the mechanism of action of known antitumor agents (e.g. acronycine, fagaronine, modified camptothecine derivatives, the morphinandienone system, crinasiatine and secamine derivatives), iv) conformational analysis of selected biologically active compounds, v) biosynthesis of selected antitumor antibiotics (e.g. staurosporine); vi) evaluation of selected plants for antineoplastic activity and fractionation for their active principles; and vii) investigation of the dose relationship between immune stimulation and cytotoxic activity. All isolates and synthetic intermediates will typically be evaluated against a broad range of in vitro test systems.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA020164-16
Application #
3165258
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1979-04-01
Project End
1994-04-30
Budget Start
1992-05-01
Budget End
1993-04-30
Support Year
16
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Type
Schools of Pharmacy
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612
Pengsuparp, T; Kingston, D G; Neidigh, K A et al. (1996) Evaluation of the cytotoxic mechanism mediated by baccatin III, the synthetic precursor of taxol. Chem Biol Interact 101:103-14
Oksuz, S; Gurek, F; Lin, L Z et al. (1996) Aleppicatines A and B from Euphorbia aleppica. Phytochemistry 42:473-8
Pengsuparp, T; Cai, L; Constant, H et al. (1995) Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase. J Nat Prod 58:1024-31
Sun, H D; Lin, Z W; Niu, F D et al. (1995) Cytotoxic ent-kaurene diterpenoids from three Isodon species. Phytochemistry 38:437-42
Gil, R R; Lin, L Z; Chai, H B et al. (1995) Cardenolides from Nierembergia aristata. J Nat Prod 58:848-56
Oksuz, S; Gurek, F; Gil, R R et al. (1995) Four diterpene esters from Euphorbia myrsinites. Phytochemistry 38:1457-62
Wang, J N; Hou, C Y; Liu, Y L et al. (1994) Swertifrancheside, an HIV-reverse transcriptase inhibitor and the first flavone-xanthone dimer, from Swertia franchetiana. J Nat Prod 57:211-7
Likhitwitayawuid, K; Angerhofer, C K; Chai, H et al. (1993) Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei. J Nat Prod 56:1468-78
Saifah, E; Puripattanavong, J; Likhitwitayawuid, K et al. (1993) Bisamides from Aglaia species: structure analysis and potential to reverse drug resistance with cultured cells. J Nat Prod 56:473-7
Somanabandhu, A; Nitayangkura, S; Mahidol, C et al. (1993) 1H- and 13C-nmr assignments of phyllanthin and hypophyllanthin: lignans that enhance cytotoxic responses with cultured multidrug-resistant cells. J Nat Prod 56:233-9

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