Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA021488-09S1
Application #
3165569
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1977-04-01
Project End
1987-07-31
Budget Start
1987-04-01
Budget End
1987-07-31
Support Year
9
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Alberta
Department
Type
DUNS #
City
Edmonton
State
AB
Country
Canada
Zip Code
T6 2E1
Reszka, K; Naghipur, A; Lown, J W (1990) Electron paramagnetic resonance and spin trapping study of radicals formed during reaction of aromatic amines with isoamyl nitrite under aprotic conditions. Free Radic Res Commun 10:47-56
Ikonomou, M G; Naghipur, A; Lown, J W et al. (1990) Characterization of the reaction products of deoxyguanosine with the anticancer agent BFNU and BFNU-1,1,1',1'-d4 in different buffers by high-performance liquid chromatography/atmospheric pressure ionization tandem mass spectrometry. Biomed Environ Mass Spectrom 19:434-46
Lown, J W; Krowicki, K; Balzarini, J et al. (1989) Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation. J Med Chem 32:2368-75
Carminati, A; Barascut, J L; Naghipur, A et al. (1989) Pathways and kinetics of aqueous decomposition and carbamoylating activity of new anticancer nitroimidazole-linked 2-chloroethylnitrosoureas. Biochem Pharmacol 38:2253-8
Bailly, C; Catteau, J P; Henichart, J P et al. (1989) Subcellular distribution of a nitroxide spin-labeled netropsin in living KB cells. Electron paramagnetic resonance and sequence specificity studies. Biochem Pharmacol 38:1625-30
Krowicki, K; Balzarini, J; De Clercq, E et al. (1988) Novel DNA groove binding alkylators: design, synthesis, and biological evaluation. J Med Chem 31:341-5
Lown, J W; Koganty, R R; Bhat, U G et al. (1986) Mechanism of interstrand cross-linking of DNA by anticancer 2-haloethylnitrosoureas. Drugs Exp Clin Res 12:463-73
Lown, J W; Koganty, R R; Bhat, U G et al. (1986) Isolation and characterization of electrophiles from 2-haloethylnitrosoureas forming cytotoxic DNA cross-links and cyclic nucleotide adducts and the analysis of base site-selectivity by ab initio calculations. IARC Sci Publ :129-36
Parker, S; Kirk, M C; Ludlum, D B et al. (1986) Reaction of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) with guanosine: evidence for a new mechanism of DNA modification. Biochem Biophys Res Commun 139:31-6
Lown, J W; Koganty, R R; Tew, K D et al. (1985) Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Pathways of aqueous decomposition and pharmacological characteristics of new anticancer disulfide-linked nitrosoureas. Biochem Pharmacol 34:1015-24