Abstract

The objectives of this ongoing research are 1) to develop new or improved quantitative methods for assessing the effects of one or more environmental exposures, especially carcinogens; and 2) to apply these methods to epidemiological and experimental data. Improved statistical techniques wil be sought in three problem areas: 1) methods for relating disease-free survival to single and multiple exposures, and application of these methods to epidemiological cohort data; 2) methods for dealing with missing values and other types of incomplete observations in multiple regression analyses of retrospective and prospective epidemiological data; 3) methods for using animal cancer bioassay data to estimate human risk from environmental carcinogens. In areas 1 and 2, particular attention will focus on methods for accommodating exposure errors when estimating disease risk due to environmental toxicants and other lifestyle factors. Data describing the mortality experience of the US uranium miner cohort, data on cancer incidence and mortality among a cohort of former college students, and data generated in animal experiments will be focal points for the development and application of improved techniques in these three areas.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA023214-08
Application #
3166047
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1978-09-01
Project End
1988-02-29
Budget Start
1986-03-01
Budget End
1987-02-28
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Lee, M M; Whittemore, A S; Lung, D L (1992) Reliability of recalled physical activity, cigarette smoking, and alcohol consumption. Ann Epidemiol 2:705-14
Pathak, D R; Whittemore, A S (1992) Combined effects of body size, parity, and menstrual events on breast cancer incidence in seven countries. Am J Epidemiol 135:153-68
Whittemore, A S (1989) Cancer risk assessment and prevention: where do we stand? Environ Health Perspect 81:95-101
Wu, M L; Whittemore, A S; Jung, D L (1988) Errors in reported dietary intakes. II. Long-term recall. Am J Epidemiol 128:1137-45
Whittemore, A S (1988) Effect of cigarette smoking in epidemiological studies of lung cancer. Stat Med 7:223-38
Halpern, J; Whittemore, A S (1987) Methods for analyzing occupational cohort data with application to lung cancer in U.S. uranium miners. J Chronic Dis 40 Suppl 2:79S-88S
Whittemore, A S (1987) Methods old and new for analyzing occupational cohort data. Am J Ind Med 12:233-48
Wu, M L; Whittemore, A S; Jung, D L (1986) Errors in reported dietary intakes. I. Short-term recall. Am J Epidemiol 124:826-35
Whittemore, A S (1986) Epidemiology in risk assessment for regulatory policy. J Chronic Dis 39:1157-68
Whittemore, A S; Keller, J B (1986) Survival estimation using splines. Biometrics 42:495-506

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