DNA Methylation and Collagen Type I Trimer in Liver

Smith, Barbara Davis

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA023540-14
• Application #: 2087179
• Study Section: General Medicine A Subcommittee 2 (GMA)
• Project Start: 1981-09-01
• Project End: 1998-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 14
• Fiscal Year: 1996

Institution

• Name: Boston University
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 604483045
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02118

Publications

Sengupta, P K; Ehrlich, M; Smith, B D (1999) A methylation-responsive MDBP/RFX site is in the first exon of the collagen alpha2(I) promoter. J Biol Chem 274:36649-55

Sengupta, P K; Smith, B D (1998) Methylation in the initiation region of the first exon suppresses collagen pro-alpha2(I) gene transcription. Biochim Biophys Acta 1443:75-89

Lim, A L; Doyle, S A; Balian, G et al. (1998) Role of the pro-alpha2(I) COOH-terminal region in assembly of type I collagen: truncation of the last 10 amino acid residues of pro-alpha2(I) chain prevents assembly of type I collagen heterotrimer. J Cell Biochem 71:216-32

Doyle, S A; Smith, B D (1998) Role of the pro-alpha2(I) COOH-terminal region in assembly of type I collagen: disruption of two intramolecular disulfide bonds in pro-alpha2(I) blocks assembly of type I collagen. J Cell Biochem 71:233-42

Lim, A; Greenspan, D S; Smith, B D (1994) Expression of alpha 2 type I collagen in W8 cells increases cell adhesion and decreases colony formation in soft agar. Matrix Biol 14:21-30

Guenette, D K; Ritzenthaler, J D; Foley, J et al. (1992) DNA methylation inhibits transcription of procollagen alpha 2(I) promoters. Biochem J 283 ( Pt 3):699-703