Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA024586-13
Application #
3166494
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1989-12-01
Project End
1993-04-30
Budget Start
1989-12-01
Budget End
1990-04-30
Support Year
13
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Florida
Department
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Lock, R B; Ross, W E (1990) Possible role for p34cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells. Cancer Res 50:3767-71
Lock, R B; Ross, W E (1990) Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells. Cancer Res 50:3761-6
Sullivan, D M; Latham, M D; Rowe, T C et al. (1989) Purification and characterization of an altered topoisomerase II from a drug-resistant Chinese hamster ovary cell line. Biochemistry 28:5680-7
Chow, K C; King, C K; Ross, W E (1988) Abrogation of etoposide-mediated cytotoxicity by cycloheximide. Biochem Pharmacol 37:1117-22
Ross, W E; Sullivan, D M; Chow, K C (1988) Altered function of DNA topoisomerases as a basis for antineoplastic drug action. Important Adv Oncol :65-81
Sullivan, D M; Latham, M D; Ross, W E (1987) Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells. Cancer Res 47:3973-9
Chow, K C; Ross, W E (1987) Topoisomerase-specific drug sensitivity in relation to cell cycle progression. Mol Cell Biol 7:3119-23
Glisson, B S; Ross, W E (1987) DNA topoisomerase II: a primer on the enzyme and its unique role as a multidrug target in cancer chemotherapy. Pharmacol Ther 32:89-106
Lock, R B; Ross, W E (1987) DNA topoisomerases in cancer therapy. Anticancer Drug Des 2:151-64
Glisson, B; Gupta, R; Hodges, P et al. (1986) Cross-resistance to intercalating agents in an epipodophyllotoxin-resistant Chinese hamster ovary cell line: evidence for a common intracellular target. Cancer Res 46:1939-42

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