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Kato, S; Burke, P J; Fenick, D J et al. (2000) Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs. Chem Res Toxicol 13:509-16
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Taatjes, D J; Fenick, D J; Koch, T H (1999) Nuclear targeting and nuclear retention of anthracycline-formaldehyde conjugates implicates DNA covalent bonding in the cytotoxic mechanism of anthracyclines. Chem Res Toxicol 12:588-96
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Taatjes, D J; Fenick, D J; Gaudiano, G et al. (1998) A redox pathway leading to the alkylation of nucleic acids by doxorubicin and related anthracyclines: application to the design of antitumor drugs for resistant cancer. Curr Pharm Des 4:203-18
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Taatjes, D J; Fenick, D J; Koch, T H (1998) Epidoxoform: a hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells. J Med Chem 41:1306-14
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Serafino, A; Sinibaldi-Vallebona, P; Gaudiano, G et al. (1998) Cytoplasmic localization of anthracycline antitumor drugs conjugated with reduced glutathione: a possible correlation with multidrug resistance mechanisms. Anticancer Res 18:1159-66
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Taatjes, D J; Gaudiano, G; Resing, K et al. (1997) Redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin. J Med Chem 40:1276-86
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Taatjes, D J; Gaudiano, G; Koch, T H (1997) Production of formaldehyde and DNA-adriamycin or DNA-daunomycin adducts, initiated through redox chemistry of dithiothreitol/iron, xanthine oxidase/NADH/iron, or glutathione/iron. Chem Res Toxicol 10:953-61
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Fenick, D J; Taatjes, D J; Koch, T H (1997) Doxoform and Daunoform: anthracycline-formaldehyde conjugates toxic to resistant tumor cells. J Med Chem 40:2452-61
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Taatjes, D J; Gaudiano, G; Resing, K et al. (1996) Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin. J Med Chem 39:4135-8
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Gaudiano, G; Koch, T H (1991) Redox chemistry of anthracycline antitumor drugs and use of captodative radicals as tools for its elucidation and control. Chem Res Toxicol 4:2-16
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