The objective of our competing renewal application for the Univ of Chicago Research Training Program in Respiratory Biology is to prepare young scientists to pursue research careers addressing mechanisms and treatment of human disease, with a focus on respiratory pathobiology. The cohesiveness of this interdisciplinary Program stems from the highly collaborative nature of our 37 well-funded faculty in 7 departments and the Institute for Molecular Engineering at the Univ of Chicago in multiple areas of concentration. Studies in Asthma and Airway Physiology/Immunology continue to focus on airway inflammation, airway smooth muscle and epithelial structure and function, B-cell and T-cell activation, asthma genetics, and clinical investigation. These complement programs of Studies in Lung Immunology and Transplantation, that focuses on cellular and molecular mechanisms underlying transplantation immunology and their translational applications to patients, and translational Studies in Interstitial Lung Diseases that draw on one of the largest dedicated clinics in the Midwest. A new Concentration in Airway and Mucosal Microbiome adds this critically important emerging research direction to the asthma and ILD programs. Studies in Critical Illness and Acute Lung Injury continue to address subcellular determinants of oxygen sensing and consumption, cellular responses to hypoxia, membrane biology, endothelial and epithelial barrier function, and bedside translations to patients with sepsis or cardiopulmonary arrest. Complementing these are cross-cutting Studies in Genetics and Epigenetics and Concentration in Health Studies and Ethics. The Program Directors are Julian Solway, MD and Anne I. Sperling, PhD with Associate Director Steven White, MD (Mentorship and Career Development). Christopher Olopade, MD, MPH chairs a Diversity Committee. Internal and External Advisors provide yearly oversight and continuity of review, and an Admissions/Steering Committee meets every 6 months to review trainee progress. We request funding for 10 post-doctoral trainees. PhD and MD trainees are both enrolled and trained together. Collaboration of basic and clinical scientists on research further enhances the integrative and translational nature of our program. All fellows perform full-time research for at least 2 years, and MD fellows will not receive clinical training while supported by this Program. Training consists of 5 major components: a Research Project performed under the direct supervision of faculty co-mentors; a Core Curriculum of robust seminar series and courses with additional, tailored formal coursework; Core Competencies that includes scientific communication, grant writing, and mentoring; Multidisciplinary Research; and (5) Individualized Career Development Planning. Prior trainees from this Program have developed successful independent research careers in large proportion. Refinements presented here should further enhance the likelihood for success of future trainees.

Public Health Relevance

Diseases of the respiratory system and of critical illness constitute major public health problem in the US and worldwide. The objective of this Program is to prepare young scientists to pursue research careers addressing mechanisms and treatment of human disease, with a focus on respiratory disease and critical illness. We expect that trainees from this Program will identify disease mechanisms and develop and implement new effective treatments that will improve human health.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007605-31
Application #
8798840
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
1985-06-01
Project End
2020-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
31
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Hrusch, C L; Manns, S T; Bryazka, D et al. (2018) ICOS protects against mortality from acute lung injury through activation of IL-5+ ILC2s. Mucosal Immunol 11:61-70
Wu, David; Woods, Parker S; Duong, Heng T et al. (2018) Role of Cellular Metabolism in Pulmonary Diseases. Am J Respir Cell Mol Biol 59:127-129
Patel, Bhakti K; Wolfe, Krysta S; MacKenzie, Erica L et al. (2018) One-Year Outcomes in Patients With Acute Respiratory Distress Syndrome Enrolled in a Randomized Clinical Trial of Helmet Versus Facemask Noninvasive Ventilation. Crit Care Med 46:1078-1084
Duong, Heng; Bonham, Catherine A (2018) Sarcoidosis-associated Pulmonary Hypertension: Pathophysiology, Diagnosis, and Treatment. Clin Pulm Med 25:52-60
Hamanaka, Robert B; Nigdelioglu, Recep; Meliton, Angelo Y et al. (2018) Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol 58:585-593
Rojas, Juan C; Carey, Kyle A; Edelson, Dana P et al. (2018) Predicting Intensive Care Unit Readmission with Machine Learning Using Electronic Health Record Data. Ann Am Thorac Soc 15:846-853
Greenberg, Jared A; Hrusch, Cara L; Jaffery, Mohammad R et al. (2018) Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality. Crit Care 22:107
Stein, Michelle M; Thompson, Emma E; Schoettler, Nathan et al. (2018) A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol 142:749-764.e3
Bonham, Catherine A; Patterson, Karen C; Strek, Mary E (2018) Asthma Outcomes and Management During Pregnancy. Chest 153:515-527
Gallo, Amy E; Parker, William F; Thistlethwaite Jr, James R et al. (2018) It is time to revise the kidney allocation system to restore the pediatric advantage. Am J Transplant 18:2365-2366

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