Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY010824-02
Application #
2164965
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1994-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Kubo, Eri; Singh, Dhirendra P; Fatma, Nigar et al. (2003) Cellular distribution of lens epithelium-derived growth factor (LEDGF) in the rat eye: loss of LEDGF from nuclei of differentiating cells. Histochem Cell Biol 119:289-99
Nishizawa, Y; Usukura, J; Singh, D P et al. (2001) Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus. Cell Tissue Res 305:107-14
Matsui, H; Lin, L R; Singh, D P et al. (2001) Lens epithelium-derived growth factor: increased survival and decreased DNA breakage of human RPE cells induced by oxidative stress. Invest Ophthalmol Vis Sci 42:2935-41
Machida, S; Chaudhry, P; Shinohara, T et al. (2001) Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats. Invest Ophthalmol Vis Sci 42:1087-95
Nakamura, M; Singh, D P; Kubo, E et al. (2000) LEDGF: survival of embryonic chick retinal photoreceptor cells. Invest Ophthalmol Vis Sci 41:1168-75
Sharma, P; Singh, D P; Fatma, N et al. (2000) Activation of LEDGF gene by thermal-and oxidative-stresses. Biochem Biophys Res Commun 276:1320-4
Fatma, N; Singh, D P; Shinohara, T et al. (2000) Heparin's roles in stabilizing, potentiating, and transporting LEDGF into the nucleus. Invest Ophthalmol Vis Sci 41:2648-57
Singh, D P; Kimura, A; Chylack Jr, L T et al. (2000) Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing. Gene 242:265-73
Ayaki, M; Sueno, T; Singh, D P et al. (1999) Antibodies to lens epithelium-derived growth factor (LEDGF) kill epithelial cells of whole lenses in organ culture. Exp Eye Res 69:139-42
Singh, D P; Sueno, T; Kikuchi, T et al. (1999) Antibodies to a microbial peptide sharing sequence homology with betaA3-crystallin damage lens epithelial cells in vitro and in vivo. Autoimmunity 29:311-22

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