Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA025344-17A1S1
Application #
2087362
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1979-06-01
Project End
2000-01-31
Budget Start
1996-02-15
Budget End
1997-01-31
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Georgetown University
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057

  Publications

Wang, Tao; Simbulan-Rosenthal, Cynthia M; Smulson, Mark E et al. (2008) Polyubiquitylation of PARP-1 through ubiquitin K48 is modulated by activated DNA, NAD+, and dipeptides. J Cell Biochem 104:318-28
Rosenthal, D S; Simbulan-Rosenthal, C M; Liu, W F et al. (2001) Mechanisms of JP-8 jet fuel cell toxicity. II. Induction of necrosis in skin fibroblasts and keratinocytes and modulation of levels of Bcl-2 family members. Toxicol Appl Pharmacol 171:107-16
Stoica, B A; Boulares, A H; Rosenthal, D S et al. (2001) Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells. Toxicol Appl Pharmacol 171:94-106
Smulson, M; Istock, N; Ding, R et al. (1994) Deletion mutants of poly(ADP-ribose) polymerase support a model of cyclic association and dissociation of enzyme from DNA ends during DNA repair. Biochemistry 33:6186-91
Stevnsner, T; Ding, R; Smulson, M et al. (1994) Inhibition of gene-specific repair of alkylation damage in cells depleted of poly(ADP-ribose) polymerase. Nucleic Acids Res 22:4620-4
Ding, R; Smulson, M (1994) Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity. Cancer Res 54:4627-34
Smulson, M E (1994) Poly(ADP-ribose) polymerase gene on chromosome 1q: early role in differentiation linked replication;gene on human chromosome 13q: marker of carcinogenesis. Mol Cell Biochem 138:77-84
Blaho, J A; Michael, N; Kang, V et al. (1992) Differences in the poly(ADP-ribosyl)ation patterns of ICP4, the herpes simplex virus major regulatory protein, in infected cells and in isolated nuclei. J Virol 66:6398-407
Ding, R; Pommier, Y; Kang, V H et al. (1992) Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining. J Biol Chem 267:12804-12
Bhatia, K; Kang, V H; Stein, G S et al. (1990) Cell cycle regulation of an exogenous human poly(ADP-ribose) polymerase cDNA introduced into murine cells. J Cell Physiol 144:345-53

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