Abstract

It has become well recognized that the presence of clonal chromosome abnormalities in patients with acute non-lymphocytic leukemia (ANLL) has prognostic importance. The goal of this project has been to establish specific subsets of association of leukemic type and chromosome abnormality. The exact type of leukemia is determined by light microscopy, cytochemical reactions, and transmission electron microscopy analysis. The specific karyotype is determined by simultaneous analysis with several methods of chromosome banding. Careful evaluation of the patient's clinical response to a standard treatment regimen will allow the correlation of specific karyotypes with remission rate and survival. Our goals for the past year were to continue to accrue patients with primary and secondary leukemias, to continue our correlations with morphology and aneuploidy, and to develop banding methodologies which could more specifically identify the presence of a chromosomal abnormality.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA025568-08
Application #
3166924
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1979-07-01
Project End
1987-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Rowley, J D (1988) Chromosome abnormalities in leukemia. J Clin Oncol 6:194-202
Larson, R A; Williams, S F; Le Beau, M M et al. (1986) Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis. Blood 68:1242-9
Le Beau, M M; Albain, K S; Larson, R A et al. (1986) Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7. J Clin Oncol 4:325-45
Le Beau, M M; Diaz, M O; Karin, M et al. (1985) Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia. Nature 313:709-11
Le Beau, M M; Bitter, M A; Kaneko, Y et al. (1985) Insertion (10;11)(p11;q23q24) in two cases of acute monocytic leukemia. Leuk Res 9:605-11
Suarez, C R; Le Beau, M M; Silberman, S et al. (1985) Acute megakaryoblastic leukemia in Down's syndrome: report of a case and review of cytogenetic findings. Med Pediatr Oncol 13:225-31
Diaz, M O; Le Beau, M M; Rowley, J D et al. (1985) The role of the c-mos gene in the 8;21 translocation in human acute myeloblastic leukemia. Science 229:767-9
Pearson, M G; Vardiman, J W; Le Beau, M M et al. (1985) Increased numbers of marrow basophils may be associated with a t(6;9) in ANLL. Am J Hematol 18:393-403
Bitter, M A; Neilly, M E; Le Beau, M M et al. (1985) Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia. Blood 66:1362-70
Diaz, M O; Le Beau, M M; Harden, A et al. (1985) Trisomy 8 in human hematologic neoplasia and the c-myc and c-mos oncogenes. Leuk Res 9:1437-42