Our overall goal in these studies is to investigate the mechanisms involved in the development of MMTV-specific natural killer cell reactivity and to determine what factors control the decline of this reactivity following spontaneous tumor development in the host neonatally infected with MMTV. We have investigated both nude (athymic) and conventional mice and have found both to possess substantial levels of antigen-specific NK activity to MMTV gp52 and p28. This reactivity declines sharply following spontaneous tumor production. We wish to determine the lineage of the NK cells both in terms of antigen commitment and end point differentiation, and to determine whether there are previously undetected subpopulations of NK cells which recognize """"""""transformation"""""""" antigens in addition to viral antigens.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA026825-08
Application #
3167461
Study Section
Experimental Immunology Study Section (EI)
Project Start
1979-09-30
Project End
1988-01-31
Budget Start
1986-02-01
Budget End
1987-01-31
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Macoska, J A; Powell, I J; Sakr, W et al. (1992) Loss of the 17p chromosomal region in a metastatic carcinoma of the prostate. J Urol 147:1142-6