Abstract

Progress with these studies has shown that: (1) patients with autologous antibody may be long term survivors; (2) the expression of the antigen defined by MAb A9 increases with tumor progression; (3) when the DNA content of primary and metastatic cancer lines from the same patient are compared, the metastatic tumor has a decreased DNA content relative to the primary when the metastatic line also exhibits a greater growth in potential in the nude mouse and in vitro; and (4) laryngeal cancers express estrogen receptors and exhibit growth inhibition in response to Tamoxifen (an antiestrogen) in vitro. (AG)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA028564-07
Application #
3168217
Study Section
Experimental Immunology Study Section (EI)
Project Start
1980-06-01
Project End
1988-07-31
Budget Start
1986-08-01
Budget End
1987-07-31
Support Year
7
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Carey, T E; Frank, C J; Raval, J R et al. (1997) Identifying genetic changes associated with tumor progression in squamous cell carcinoma. Acta Otolaryngol Suppl 529:229-32
Frank, C J; McClatchey, K D; Devaney, K O et al. (1997) Evidence that loss of chromosome 18q is associated with tumor progression. Cancer Res 57:824-7
Jones, J W; Raval, J R; Beals, T F et al. (1997) Frequent loss of heterozygosity on chromosome arm 18q in squamous cell carcinomas. Identification of 2 regions of loss--18q11.1-q12.3 and 18q21.1-q23. Arch Otolaryngol Head Neck Surg 123:610-4
Kelker, W; Van Dyke, D L; Worsham, M J et al. (1996) Loss of 18q and homozygosity for the DCC locus: possible markers for clinically aggressive squamous cell carcinoma. Anticancer Res 16:2365-72
Carey, T E; Nair, T S; Chern, C et al. (1993) Blood group antigens and integrins as biomarkers in head and neck cancer: is aberrant tyrosine phosphorylation the cause of altered alpha 6 beta 4 integrin expression? J Cell Biochem Suppl 17F:223-32
Vlock, D R; Arnold, B; Humpierres, J et al. (1992) Serial studies of autologous antibody reactivity to squamous cell carcinoma of the head and neck. Cancer Immunol Immunother 34:329-36
Grenman, R; Carey, T E; McClatchey, K D et al. (1991) In vitro radiation resistance among cell lines established from patients with squamous cell carcinoma of the head and neck. Cancer 67:2741-7
Bradford, C R; Zacks, S E; Androphy, E J et al. (1991) Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas. Otolaryngol Head Neck Surg 104:303-10
Bradford, C R; Kimmel, K A; Van Dyke, D L et al. (1991) 11p deletions and breakpoints in squamous cell carcinoma: association with altered reactivity with the UM-E7 antibody. Genes Chromosomes Cancer 3:272-82
Wolf, G T; Carey, T E; Schmaltz, S P et al. (1990) Altered antigen expression predicts outcome in squamous cell carcinoma of the head and neck. J Natl Cancer Inst 82:1566-72

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