Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA029414-09S1
Application #
3168701
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1981-02-01
Project End
1991-12-31
Budget Start
1990-01-01
Budget End
1991-12-31
Support Year
9
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Temple University
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Wang, X; Sirover, M A; Anderson, L E (1999) Pea chloroplast glyceraldehyde-3-phosphate dehydrogenase has uracil glycosylase activity. Arch Biochem Biophys 367:348-53
Sirover, M A (1996) Minireview. Emerging new functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells. Life Sci 58:2271-7
Wurzer, J C; Tallarida, R J; Sirover, M A (1994) New mechanism of action of the cancer chemotherapeutic agent 5-fluorouracil in human cells. J Pharmacol Exp Ther 269:39-43
Weng, Y; Sirover, M A (1993) Developmental regulation of the base excision repair enzyme uracil DNA glycosylase in the rat. Mutat Res 293:133-41
Mansur, N R; Meyer-Siegler, K; Wurzer, J C et al. (1993) Cell cycle regulation of the glyceraldehyde-3-phosphate dehydrogenase/uracil DNA glycosylase gene in normal human cells. Nucleic Acids Res 21:993-8
Mauro, D J; De Riel, J K; Tallarida, R J et al. (1993) Mechanisms of excision of 5-fluorouracil by uracil DNA glycosylase in normal human cells. Mol Pharmacol 43:854-7
Meyer-Siegler, K; Rahman-Mansur, N; Wurzer, J C et al. (1992) Proliferative dependent regulation of the glyceraldehyde-3-phosphate dehydrogenase/uracil DNA glycosylase gene in human cells. Carcinogenesis 13:2127-32
Seal, G; Tallarida, R J; Sirover, M A (1991) Purification and properties of the uracil DNA glycosylase from Bloom's syndrome. Biochim Biophys Acta 1097:299-308
Meyer-Siegler, K; Mauro, D J; Seal, G et al. (1991) A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A 88:8460-4
Cool, B L; Sirover, M A (1990) Proliferation-dependent regulation of DNA glycosylases in progeroid cells. Mutat Res 237:211-20

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