Abstract

The response of normal tissues to multiple doses of radiation will be quantitated with a view to understanding differences in response to various tissues to the daily doses used in clinical radiotherapy. The tissue cells to be studied are bone marrow stem cells, using an endogenous spleen colony assay, hair follicle cells using a hair counting technique and renal tubule cells using a cloning technique. Doses of the order of 50 to 500 rad will be given in each dose fraction and the effect scored at appropriate intervals after exposure. It is anticipated that small differences in response at low doses will be amplified by repeated exposures, allowing more precise quantitation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA029644-09
Application #
3168820
Study Section
Radiation Study Section (RAD)
Project Start
1980-07-01
Project End
1990-03-31
Budget Start
1988-07-01
Budget End
1990-03-31
Support Year
9
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Taylor, J M; Withers, H R; Mason, K A et al. (1991) Repopulation of mouse jejunal crypt cells. Radiother Oncol 20:181-90
Maciejewski, B; Withers, H R; Taylor, J M et al. (1990) Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx. Part 2. Normal tissue responses: acute and late effects. Int J Radiat Oncol Biol Phys 18:101-11
Mason, K A; Withers, H R; Davis, C A (1989) Dose dependent latency of fatal gastrointestinal and bone marrow syndromes. Int J Radiat Biol 55:1-5
Vegesna, V; Withers, H R; Taylor, J M (1989) Differential response of rapidly- and slowly-proliferating hair follicles of mice to fractionated irradiation. Int J Radiat Oncol Biol Phys 17:1027-31
McBride, W H; Mason, K A; Davis, C et al. (1989) Adhesion formation in experimental chronic radiation enteropathy. Int J Radiat Oncol Biol Phys 16:737-43
Vegesna, V; Withers, H R; Taylor, J M (1989) Repair kinetics of mouse lung. Radiother Oncol 15:115-23
Maciejewski, B; Withers, H R; Taylor, J M et al. (1989) Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx: tumor dose-response and repopulation. Int J Radiat Oncol Biol Phys 16:831-43
Mason, K A; Withers, H R; McBride, W H et al. (1989) Comparison of the gastrointestinal syndrome after total-body or total-abdominal irradiation. Radiat Res 117:480-8
Withers, H R (1989) Radiobiological philosophy of current U.S. neutron trials. Strahlenther Onkol 165:294-7
Withers, H R (1988) Some changes in concepts of dose fractionation over 20 years. Front Radiat Ther Oncol 22:1-13

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