Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA030187-06S1
Application #
3169114
Study Section
Experimental Immunology Study Section (EI)
Project Start
1981-02-01
Project End
1988-06-30
Budget Start
1988-05-01
Budget End
1988-06-30
Support Year
6
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Umehara, H; Takashima, A; Minami, Y et al. (1993) Signal transduction via phosphorylated adhesion molecule, LFA-1 beta (CD18), is increased by culture of natural killer cells with IL-2 in the generation of lymphokine-activated killer cells. Int Immunol 5:19-27
Naliboff, B D; Benton, D; Solomon, G F et al. (1991) Immunological changes in young and old adults during brief laboratory stress. Psychosom Med 53:121-32
Makinodan, T; Hahn, T J; McDougall, S et al. (1991) Cellular immunosenescence: an overview. Exp Gerontol 26:281-8
Bloom, E T; Umehara, H; Bleackley, R C et al. (1990) Age-related decrement in cytotoxic T lymphocyte (CTL) activity is associated with decreased levels of mRNA encoded by two CTL-associated serine esterase genes and the perforin gene in mice. Eur J Immunol 20:2309-16
Bloom, E T; Babbitt, J T (1990) Prostaglandin E2, monocyte adherence and interleukin-1 in the regulation of human natural killer cell activity by monocytes. Nat Immun Cell Growth Regul 9:36-48
Umehara, H; Bloom, E T (1990) The IL-2 receptor beta subunit is absolutely required for mediating the IL-2-induced activation of NK activity and proliferative activity of human large granular lymphocytes. Immunology 70:111-5
Fong, T C; Babbitt, J T; Bloom, E T (1989) Increase in Tac mRNA expression in natural killer-like cell line in response to interleukin-1 and interleukin-2 shown at the population and cellular level by in situ hybridization. Nat Immun Cell Growth Regul 8:165-72
Fiatarone, M A; Morley, J E; Bloom, E T et al. (1989) The effect of exercise on natural killer cell activity in young and old subjects. J Gerontol 44:M37-45
Bloom, E T; Kubota, L F (1989) Effect of IL-2 in vitro on CTL generation in spleen cells of young and old mice: asialo GM1+ cells are required for the apparent restoration of the CTL response. Cell Immunol 119:73-84
Bloom, E T; Kubota, L F; Kawakami, K (1988) Age-related decline in the lethal hit but not the binding stage of cytotoxic T-cell activity in mice. Cell Immunol 114:440-6

Showing the most recent 10 out of 25 publications