Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA030251-07S1
Application #
3169145
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1981-07-01
Project End
1988-02-29
Budget Start
1988-01-01
Budget End
1988-02-29
Support Year
7
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Osborne, C K (1998) Tamoxifen in the treatment of breast cancer. N Engl J Med 339:1609-18
Nicholson, R I; Gee, J M; Bryant, S et al. (1996) Pure antiestrogens. The most important advance in the endocrine therapy of breast cancer since 1896. Ann N Y Acad Sci 784:325-35
Osborne, C K; Coronado-Heinsohn, E B; Hilsenbeck, S G et al. (1995) Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer. J Natl Cancer Inst 87:746-50
Osborne, C K; Jarman, M; McCague, R et al. (1994) The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth. Cancer Chemother Pharmacol 34:89-95
Koester, S K; Maenpaa, J U; Wiebe, V J et al. (1994) Flow cytometry: potential utility in monitoring drug effects in breast cancer. Breast Cancer Res Treat 32:57-65
Maenpaa, J; Wiebe, V; Wurz, G et al. (1994) Reduced tamoxifen accumulation is not associated with stimulated growth in tamoxifen resistance. Cancer Chemother Pharmacol 35:149-52
Maenpaa, J U; Wurz, G T; Baker, W J et al. (1993) A breast cancer clone selected by tamoxifen has increased growth rate and reduced sensitivity to doxorubicin. Oncol Res 5:461-6
Encarnacion, C A; Ciocca, D R; McGuire, W L et al. (1993) Measurement of steroid hormone receptors in breast cancer patients on tamoxifen. Breast Cancer Res Treat 26:237-46
Osborne, C K (1993) Mechanisms for tamoxifen resistance in breast cancer: possible role of tamoxifen metabolism. J Steroid Biochem Mol Biol 47:83-9
Wiebe, V J; Osborne, C K; Fuqua, S A et al. (1993) Tamoxifen resistance in breast cancer. Crit Rev Oncol Hematol 14:173-88

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