Abstract

Support for continuation of a long-term study directed at the isolation, characterization and structural elucidation of new and potentially useful cancer chemotherapeutic drugs from terrestrial plants has been summarized. Research will continue to be devoted to plant species yielding extracts with a very significant confirmed level of activity in the National Cancer Institute's murine P-388 lymphocytic leukemia screening program. Once each plant problem has been solved or discontinued (due to lost activity) another high priority plant will be selected for study. Plants continue to be excellent sources of new drugs for cancer treatment. Discovery of useful cancer chemotherapeutic drugs for human cancer treatment continues to be exceedingly important and most necessary research objective so the overall grant program is expected to be quite productive and provide very significant results.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA030311-02
Application #
3169218
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1985-09-01
Project End
1988-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Arizona State University-Tempe Campus
Department
Type
Schools of Arts and Sciences
DUNS #
188435911
City
Tempe
State
AZ
Country
United States
Zip Code
85287

  Publications

Pettit, G R; Doubek, D L; Herald, D L et al. (1991) Isolation and structure of cytostatic steroidal saponins from the African medicinal plant Balanites aegyptica. J Nat Prod 54:1491-502
Pettit, G R; Cragg, G M; Singh, S B et al. (1990) Antineoplastic agents, 162. Zephyranthes candida. J Nat Prod 53:176-8
Singh, S B; Pettit, G R (1990) Antineoplastic agents, 195. Isolation and structure of aceratioside from Aceratium megalospermum. J Nat Prod 53:1187-92
Pettit, G R; Schaufelberger, D E; Nieman, R A et al. (1990) Antineoplastic agents, 177. Isolation and structure of phyllanthostatin 6. J Nat Prod 53:1406-13
Pettit, G R; Numata, A; Takemura, T et al. (1990) Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia. J Nat Prod 53:456-8
Pettit, G R; Herald, D L; Cragg, G M et al. (1990) Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the South American Lychnophora antillana. J Nat Prod 53:382-90
Lin, C M; Ho, H H; Pettit, G R et al. (1989) Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin. Biochemistry 28:6984-91
Pettit, G R; Singh, S B; Hamel, E et al. (1989) Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4. Experientia 45:209-11
Pettit, G R; Singh, S B; Schmidt, J M et al. (1988) Isolation, structure, synthesis, and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum. J Nat Prod 51:517-27
Pettit, G R; Schaufelberger, D E (1988) Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A. J Nat Prod 51:1104-12

Showing the most recent 10 out of 13 publications