Abstract

It has been well established by human epidemiological studies and laboratory animal investigations that quantitative differences in dietary fat can affect mammary tumor development. Recently, our laboratory has provided evidence that qualitative differences in the polyunsaturated fatty acid composition (omega-3 vs omega-6) of the dietary lipids also can significantly modify mammary tumor development. Both qualitative and quantitative dietary lipid modifications appear to mediate their effects during the post- initiation phase of tumor development and are greatly affected by the ambient hormone environment. The biochemical processes responsible for these dietary lipid effects on tumor development are poorly understood, but the data available indicate that diet induced alterations in tumor membrane lipids may be particularly important. It is hypothesized that such membrane alterations may affect tumor cell function and development by modifying the composition of the substrate lipid molecules available for post-receptor signal processing. Many polypeptide hormones and autocrine growth factors are known to initiate their actions on tumor cells through membrane receptors. The objective of this study is to test this hypothesis by searching for specific changes in eicosanoid metabolism and hormone responsiveness of mammary tumors from rats maintained on different lipid diets. Particular effort will be made to biochemically define the phospolipid and fatty acid changes in the membrane lipids induced by diets containing varying amounts of omega-3 polyunsaturated fatty acids and observing the """"""""in vivo"""""""" and """"""""in vitro"""""""" changes in eicosanoid metabolism associated with them. It is hoped that this information will help provide a rational scientific basis for future development of effective nutritional and/or pharmacological approaches to human breast cancer prevention and therapy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA030629-09
Application #
3169325
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1981-08-01
Project End
1992-09-30
Budget Start
1990-04-01
Budget End
1992-09-30
Support Year
9
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627