Abstract

The long-term goals of this proposal are to investigate the mechanisms by which: a) Fc fragments of immunoglobulin (Ig) activate human bone marrow-derived (B) lymphocytes, thymus-derived (T) lymphocytes, and monocytes; b) Fc fragments regulate in vitro immune responses; c) map the various biological functions associated with Fc fragments to discrete regions of the molecule. Upon determining the active sequence, peptides will be synthesized and assessed for biological activity. The observation that Fc fragments modulate in vitro humoral and cell-mediated immune responses suggests that this physiologic molecule may be useful as an immunotherapeutic agent in immunodeficency states and cancer management. In order to determine the in vivo applicability of fc fragments as an immune response modifier, it is necessary to understand how Fc fragments and Fc fragment-induced biologically active mediators interact with lymphoid cells and each other in regulating immune reactivity. A comprehensive program has been outlined to use Fc fragments as model system for human B cell activation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA030654-08
Application #
3169349
Study Section
Experimental Immunology Study Section (EI)
Project Start
1981-07-15
Project End
1989-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
8
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037

  Publications

Morgan, E L; Hobbs, M V; Thoman, M L et al. (1990) Induction of human B cell differentiation by Fc region activators. II. Stimulation of IL-6 production. J Immunol 144:2499-505
Morgan, E L; Hobbs, M V; Noonan, D J et al. (1988) Induction of IL-1 secretion from human monocytes by Fc region subfragments of human IgG1. J Immunol 140:3014-20
Morgan, E L (1987) The role of prostaglandins in C3a-mediated suppression of human in vitro polyclonal antibody responses. Clin Immunol Immunopathol 44:1-11
Morgan, E L; Weigle, W O (1987) Biological activities residing in the Fc region of immunoglobulin. Adv Immunol 40:61-134
Morgan, E L; Scheuer, W V; Hobbs, M V (1986) Antagonistic regulatory properties of the Fc region of immunoglobulin. Immunopharmacology 12:221-32
Hobbs, M V; Morgan, E L; Weigle, W O (1985) Bifunctional lymphocyte regulation by human Fc gamma fragments and a synthetic peptide, p23, derived from the Fc region. Immunol Lett 9:201-6