DNA Methyl Adducts: Toxicity, Mutation, & Transformation

Grisham, Joe W.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 3R01CA032036-03S1
• Application #: 3170093
• Study Section: Chemical Pathology Study Section (CPA)
• Project Start: 1982-05-01
• Project End: 1986-02-28
• Budget Start: 1984-05-01
• Budget End: 1986-02-28
• Support Year: 3
• Fiscal Year: 1986

Institution

• Name: University of North Carolina Chapel Hill
• Type: Schools of Medicine
• DUNS #: 078861598
• City: Chapel Hill
• State: NC
• Country: United States
• Zip Code: 27599

Publications

Grisham, J W; Smith, G J; Lee, L W et al. (1988) Induction of foci of morphologically transformed cells in synchronized populations of 10T1/2 cells by N-methyl-N'-nitro-N-nitrosoguanidine and the effect of spontaneous transformation on calculated transformation frequency. Cancer Res 48:5977-83

Grisham, J W; Smith, G J; Lee, L W et al. (1988) Spontaneous formation of foci of morphologically transformed cells in populations of C3H 10T1/2 (clone 8) cells. Cancer Res 48:5969-76

Jone, C; Trosko, J E; Chang, C C (1987) Characterization of a rat liver epithelial cell line to detect inhibitors of metabolic cooperation. In Vitro Cell Dev Biol 23:214-20

Smith, G J; Grisham, J W (1987) Activation of the Ha-ras gene in C3H 10T1/2 cells transformed by exposure to N-methyl-N'-nitro-N-nitrosoguanidine. Biochem Biophys Res Commun 147:1194-9

Tsao, M S; Earp, H S; Grisham, J W (1986) The effects of epidermal growth factor and the state of confluence on enzymatic activities of cultured rat liver epithelial cells. J Cell Physiol 126:167-73