Abstract

The goal of this research is to seek identifiable genetic markers whose inheritance is linked with that of multiple endocrine neoplasia, type II (MEN II), and to screen individuals to detect preclinical onset of the disease. Approximately 240 individuals will be screened for a wide variety of genetic markers in the attempt to identify genetic marker loci that are closely linked to the locus at which the cancer gene is segregating. This information will be used to identify individuals at high risk for inheriting the gene. Endocrinological screening is continued in the attempt to detect early manifestations of the disease in sufficient time so that advanced carcinoma can be avoided. (5)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA032066-08
Application #
3170110
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1983-06-01
Project End
1992-09-29
Budget Start
1991-06-01
Budget End
1992-09-29
Support Year
8
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Gill, J R; Reyes-Mugica, M; Iyengar, S et al. (1996) Early presentation of metastatic medullary carcinoma in multiple endocrine neoplasia, type IIA: implications for therapy. J Pediatr 129:459-64
Lichter, J B; Difilippantonio, M J; Pakstis, A J et al. (1993) Physical and genetic maps for chromosome 10. Genomics 16:320-4
Lichter, J B; Wu, J; Brooks-Wilson, A R et al. (1993) A new polymorphic marker (D10S97) tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus. Hum Genet 90:516-20
Brooks-Wilson, A R; Lichter, J B; Ward, D C et al. (1993) Genomic and yeast artificial chromosome long-range physical maps linking six loci in 10q11.2 and spanning the multiple endocrine neoplasia type 2A (MEN2A) region. Genomics 17:611-7
Lichter, J B; Difilippantonio, M; Wu, J et al. (1992) Localization of the gene for MEN 2A. Henry Ford Hosp Med J 40:199-204
Lichter, J B; Wu, J S; Genel, M et al. (1992) Presymptomatic testing using DNA markers for individuals at risk for familial multiple endocrine neoplasia 2A. J Clin Endocrinol Metab 74:368-73
Lichter, J B; Wu, J; Miller, D et al. (1992) A high-resolution meiotic mapping panel for the pericentromeric region of chromosome 10. Genomics 13:607-12
Wu, J S; Carson, N L; Myers, S et al. (1990) The genetic defect in multiple endocrine neoplasia type 2A maps next to the centromere of chromosome 10. Am J Hum Genet 46:624-30
Wu, J S; Kidd, K K (1990) Extensive sequence polymorphisms associated with chromosome 10 alpha satellite DNA and its close linkage to markers from the pericentromeric region. Hum Genet 84:279-82
Wu, J S; Myers, S; Carson, N et al. (1990) A refined linkage map for DNA markers around the pericentromeric region of chromosome 10. Genomics 8:461-8

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