In the tumor-dormant state intended for further study, small numbers of lethal L5178Y lymphoma cells persist in the peritoneal cavity of clinically normal DBA/2 mice for many weeks before growing out to produce an ascitic tumor. We have identified host cells involved in the establishment, maintenance, and termination of the tumor-dormant state. We intend here to modulate the growth-restraint mechanisms that maintain the tumor cells in a dormant state and to manipulate the dormant tumor cell population so as to either prolong or terminate the tumor-dormant state. We will further characterize the tumor cells isolated at various stages of tumor-dormant state and evaluate the effects of pregnancy and stress on the tumor-dormant state. (MI)

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA032577-08
Application #
3170461
Study Section
Experimental Immunology Study Section (EI)
Project Start
1981-09-30
Project End
1990-06-30
Budget Start
1988-07-01
Budget End
1990-06-30
Support Year
8
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Hahnemann University
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129
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