Abstract

In the tumor-dormant state intended for further study, small numbers of lethal L5178Y lymphoma cells persist in the peritoneal cavity of clinically normal DBA/2 mice for many weeks before growing out to produce an ascitic tumor. We have identified host cells involved in the establishment, maintenance, and termination of the tumor-dormant state. We intend here to modulate the growth-restraint mechanisms that maintain the tumor cells in a dormant state and to manipulate the dormant tumor cell population so as to either prolong or terminate the tumor-dormant state. We will further characterize the tumor cells isolated at various stages of tumor-dormant state and evaluate the effects of pregnancy and stress on the tumor-dormant state. (MI)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA032577-08
Application #
3170461
Study Section
Experimental Immunology Study Section (EI)
Project Start
1981-09-30
Project End
1990-06-30
Budget Start
1988-07-01
Budget End
1990-06-30
Support Year
8
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Hahnemann University
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129

  Publications

Yang, G; Coffman, F D; Wheelock, E F (1994) Characterization and purification of a macrophage-triggering factor produced in Mycoplasma arginini-infected L5178Y cell cultures. J Immunol 153:2579-91
Liu, C M; Suzuki, Y; Chen, L P et al. (1990) Maintenance and cure of the L5178Y murine tumor-dormant state by interleukin 2: in vivo and in vitro effects. Cancer Res 50:1361-7
Chen, L P; Suzuki, Y; Liu, C M et al. (1990) Maintenance and cure of the L5178Y murine tumor-dormant state by interleukin 2: dependence of interleukin 2 on induced interferon-gamma and on tumor necrosis factor for its antitumor effects. Cancer Res 50:1368-74
Suzuki, Y; Chen, L P; Liu, C M et al. (1989) Immune regulation of the L5178Y murine tumor-dormant state: induction of cell- and soluble factor-mediated inhibition of tumor cell growth by tumor necrosis factor and gamma-interferon. Cancer Res 49:2028-33
Suzuki, Y; Liu, C M; Chen, L P et al. (1987) Immune regulation of the L5178Y murine tumor-dormant state. II. Interferon-gamma requires tumor necrosis factor to restrain tumor cell growth in peritoneal cell cultures from tumor-dormant mice. J Immunol 139:3146-52
Chen, L; Suzuki, Y; Wheelock, E F (1987) Interferon-gamma synergizes with tumor necrosis factor and with interleukin 1 and requires the presence of both monokines to induce antitumor cytotoxic activity in macrophages. J Immunol 139:4096-101
Liu, C M; Okayasu, T; Goldman, P et al. (1986) Immune regulation of the L5178Y murine tumor-dormant state. I. In vivo and in vitro effects of prostaglandin E2 and indomethacin on tumor cell growth. J Exp Med 164:1259-73
Okayasu, T; Wheelock, E F (1986) Rapidly reversible resistance to immune lysis of L5178Y lymphoma cells in a tumor-dormant state in DBA/2 mice. J Natl Cancer Inst 76:1199-204