In this project we will continue clinical trials of monoclonal antibodies in human lymphoma. We will focus on B cell lymphoma using custom-made anti-idiotype antibodies since this is the area in which the best results have so far been obtained. Refinements will be made in patient selection, antibody development and production and mode of antibody administration in order to take advantage of the information generated in our earlier trials and to improve the clinical results. The clinical and biological correlates of tumor response will be defined by studies on the antibodies, the tumor and the host. Each patient's tumor will be studied for genetic heterogeneity by immunoglobulin gene rearrangements and by multiple different anti-idiotype antibodies. In this way, we hope to continue to gain insights into the biology of human lymphoid malignancy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA033399-04
Application #
3171292
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1982-07-01
Project End
1988-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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Irish, Jonathan M; Myklebust, June H; Alizadeh, Ash A et al. (2010) B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression. Proc Natl Acad Sci U S A 107:12747-54
Nicodemus, Christopher F; Wang, Lin; Lucas, Julie et al. (2010) Toll-like receptor-3 as a target to enhance bioactivity of cancer immunotherapy. Am J Obstet Gynecol 202:608.e1-8

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