Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA034014-03S1
Application #
3171742
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1983-02-01
Project End
1986-06-30
Budget Start
1985-02-01
Budget End
1986-06-30
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Fukuda, M N; Masri, K A; Dell, A et al. (1990) Incomplete synthesis of N-glycans in congenital dyserythropoietic anemia type II caused by a defect in the gene encoding alpha-mannosidase II. Proc Natl Acad Sci U S A 87:7443-7
Aoki, D; Appert, H E; Johnson, D et al. (1990) Analysis of the substrate binding sites of human galactosyltransferase by protein engineering. EMBO J 9:3171-8
Fukuda, M N; Masri, K A; Dell, A et al. (1989) Defective glycosylation of erythrocyte membrane glycoconjugates in a variant of congenital dyserythropoietic anemia type II: association of low level of membrane-bound form of galactosyltransferase. Blood 73:1331-9
Masri, K A; Appert, H E; Fukuda, M N (1988) Identification of the full-length coding sequence for human galactosyltransferase (beta-N-acetylglucosaminide: beta 1,4-galactosyltransferase). Biochem Biophys Res Commun 157:657-63
Fukuda, M N; Dell, A; Scartezzini, P (1987) Primary defect of congenital dyserythropoietic anemia type II. Failure in glycosylation of erythrocyte lactosaminoglycan proteins caused by lowered N-acetylglucosaminyltransferase II. J Biol Chem 262:7195-206
Howard, D R; Fukuda, M; Fukuda, M N et al. (1987) The GDP-fucose:N-acetylglucosaminide 3-alpha-L-fucosyltransferases of LEC11 and LEC12 Chinese hamster ovary mutants exhibit novel specificities for glycolipid substrates. J Biol Chem 262:16830-7
Izhar, M; Siebert, P D; Oshima, R G et al. (1986) Trophoblastic differentiation of human teratocarcinoma cell line HT-H1. Dev Biol 116:510-8
Fukuda, M N; Bothner, B; Lloyd, K O et al. (1986) Structures of glycosphingolipids isolated from human embryonal carcinoma cells. The presence of mono- and disialosyl glycolipids with blood group type 1 sequence. J Biol Chem 261:5145-53
Fukuda, M N; Klier, G; Yu, J et al. (1986) Anomalous clustering of underglycosylated band 3 in erythrocytes and their precursor cells in congenital dyserythropoietic anemia type II. Blood 68:521-9
Fukuda, M N; Bothner, B; Scartezzini, P et al. (1986) Isolation and characterization of poly-N-acetyllactosaminylceramides accumulated in the erythrocytes of congenital dyserythropoietic anemia type II patients. Chem Phys Lipids 42:185-97

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