Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA034680-07
Application #
3172447
Study Section
Radiation Study Section (RAD)
Project Start
1988-12-15
Project End
1990-07-31
Budget Start
1988-12-15
Budget End
1989-07-31
Support Year
7
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Umans, R S; Kennedy, A R (1992) Effects of activators and inhibitors of protein kinase C on X-ray induced malignant transformation in vitro. Eur J Cancer 28A:732-5
Su, L N; Toscano Jr, W A; Kennedy, A R (1991) Suppression of phorbol ester-enhanced radiation-induced malignancy in vitro by protease inhibitors is independent of protein kinase C. Biochem Biophys Res Commun 176:18-24
Flick, M B; Kennedy, A R (1991) Effect of protease inhibitors on DNA amplification in SV40-transformed Chinese hamster embryo cells. Cancer Lett 56:103-8
Kennedy, A R (1991) Is there a critical target gene for the first step in carcinogenesis? Environ Health Perspect 93:199-203
Radner, B S; Kennedy, A R (1990) Suppression of x-ray induced transformation by Valium and aspirin in mouse C3H10T1/2 cells. Cancer Lett 51:49-57
Kennedy, A R (1989) Relevance of in vitro transformation systems to skin carcinogenesis in vivo. Prog Clin Biol Res 298:103-12
Kennedy, A R; Umans, R S (1988) Effects of glucocorticoid hormones on radiation induced and 12-O-tetradecanoylphorbol-13-acetate enhanced radiation transformation in vitro. Cancer Lett 40:169-75
Umans, R S; Kennedy, A R (1988) Effects of estrogen antagonists on estradiol-enhanced radiation transformation in vitro. Cancer Lett 40:177-83
Billings, P C; St Clair, W; Ryan, C A et al. (1987) Inhibition of radiation-induced transformation of C3H/10T1/2 cells by chymotrypsin inhibitor 1 from potatoes. Carcinogenesis 8:809-12
Umans, R S; Kennedy, A R (1987) Effects of testosterone and dihydrotestosterone on malignant transformation in C3H10T 1/2 cells. Eur J Cancer Clin Oncol 23:339-42

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