Molecular & Electronic Struct of Antifolate Drugs

Cody, Vivian

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 3R01CA034714-01A1S1
• Application #: 3172480
• Study Section: Biophysics and Biophysical Chemistry A Study Section (BBCA)
• Project Start: 1984-07-01
• Project End: 1987-06-30
• Budget Start: 1984-07-01
• Budget End: 1985-06-30
• Support Year: 1
• Fiscal Year: 1985

Institution

• Name: Hauptman-Woodward Medical Research Institute
• DUNS #: 074025479
• City: Buffalo
• State: NY
• Country: United States
• Zip Code: 14203

Publications

Cody, V; Wojtczak, A; Kalman, T I et al. (1993) Conformational analysis of human dihydrofolate reductase inhibitor complexes: crystal structure determination of wild type and F31 mutant binary and ternary inhibitor complexes. Adv Exp Med Biol 338:481-6

Cody, V; Luft, J R; Ciszak, E et al. (1992) Crystal structure determination at 2.3 A of recombinant human dihydrofolate reductase ternary complex with NADPH and methotrexate-gamma-tetrazole. Anticancer Drug Des 7:483-91

Cody, V; Ciszak, E (1991) Computer graphic modeling in drug design--conformational analysis of antifolate binding to avian dihydrofolate reductase: crystal and molecular structures of 2,4-diamino-5-cyclohexyl-6-methylpyrimidine and 5-cyclohexyl-6-methyluracil. Anticancer Drug Des 6:83-93

Sutton, P A; Cody, V (1989) Structure of 1-amidino-3-(3-sulfamoylphenyl)urea hydrochloride. Acta Crystallogr C 45 ( Pt 5):757-60

Sutton, P A; Cody, V (1987) Conformational analysis of antineoplastic antifolates: the crystal structure of trimetrexate and the aminopterine derivative 4-[N-[(2,4-diamino-6-pteridinyl)methyl]amino]benzoic acid. J Med Chem 30:1843-8