These experiments will study the genes responsible for certain T-lymphocyte-specific functions. These will include genes coding for T-cell receptors as well as for the cytolytic activity of T-killer cells. With the new findings by several laboratories on the proteins and genes that correspond to putative T-cell receptors, more defined questions about T-cell receptors can now be asked. We have begun a collaboration with Drs. R. Rich and J. Allison, University of Texas, to clone the receptor genes from a cytolytic T-cell line. The approach will be to produce cDNA clones that have been made T cell specific after elimination of cDNAs that hybridize with the RNA of B cells or other cells. The combined expertise in cellular immunology of Dr. Rich's laboratory and in immunochemistry of Dr. Allison's laboratory will allow the definitive functional testing of the T-cell receptors encoded by the genes we are about to clone. (SR)
| Storb, U (1987) Transgenic mice with immunoglobulin genes. Annu Rev Immunol 5:151-74 |
| Storb, U; Ritchie, K A; O'Brien, R et al. (1986) Expression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes. Immunol Rev 89:85-102 |
| Storb, U; Pinkert, C; Arp, B et al. (1986) Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies. J Exp Med 164:627-41 |
| Storb, U; Denis, K A; Brinster, R L et al. (1985) Pre-B cells in kappa-transgenic mice. Nature 316:356-8 |
