Naphthyridinomycin is a metabolite produced by a strain of Streptomyces. This compound was shown to have an unusual and complex heterocyclic structure. Some simple semisynthetic derivatives of naphthyridinomycin have been found to have significant inhibitory activity against the P-388 lymphoid leukemia system in mice. A strategy for total syntheses of naphthyridinomycin has been proposed which should allow for an efficient stereoselective preparation of this metabolite. It is hoped that this work will also provide some unnatural analogs of naphthyridinomycin for testing as anticancer agents by NCI.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA036023-02
Application #
3173528
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1984-03-01
Project End
1987-02-28
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Type
Schools of Arts and Sciences
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802