Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA036039-04S1
Application #
3173542
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1983-06-01
Project End
1988-02-28
Budget Start
1988-01-01
Budget End
1988-02-28
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Nebraska Medical Center
Department
Type
Overall Medical
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198
Kroning, R; Jones, J A; Hom, D K et al. (1995) Enhancement of drug sensitivity of human malignancies by epidermal growth factor. Br J Cancer 72:615-9
Eastman, A; Barry, M A (1992) The origins of DNA breaks: a consequence of DNA damage, DNA repair, or apoptosis? Cancer Invest 10:229-40
Jennerwein, M M; Eastman, A; Khokhar, A R (1991) The role of DNA repair in resistance of L1210 cells to isomeric 1,2-diaminocyclohexaneplatinum complexes and ultraviolet irradiation. Mutat Res 254:89-96
Eastman, A (1991) Analysis and quantitation of the DNA damage produced in cells by the cisplatin analog cis-[3H]dichloro(ethylenediamine)platinum (II). Anal Biochem 197:311-5
Sheibani, N; Eastman, A (1990) Analysis of various mRNA potentially involved in cisplatin resistance of murine leukemia L1210 cells. Cancer Lett 52:179-85
Barry, M A; Behnke, C A; Eastman, A (1990) Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem Pharmacol 40:2353-62
Sorenson, C M; Barry, M A; Eastman, A (1990) Analysis of events associated with cell cycle arrest at G2 phase and cell death induced by cisplatin. J Natl Cancer Inst 82:749-55
Jennerwein, M M; Eastman, A; Khokhar, A (1989) Characterization of adducts produced in DNA by isomeric 1,2-diaminocyclohexaneplatinum(II) complexes. Chem Biol Interact 70:39-49
Sheibani, N; Jennerwein, M M; Eastman, A (1989) DNA repair in cells sensitive and resistant to cis-diamminedichloroplatinum(II): host cell reactivation of damaged plasmid DNA. Biochemistry 28:3120-4
Sorenson, C M; Eastman, A (1988) Mechanism of cis-diamminedichloroplatinum(II)-induced cytotoxicity: role of G2 arrest and DNA double-strand breaks. Cancer Res 48:4484-8

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