In contrast to the impressive body of information about serologically defined surface antigens of mouse leukemia cells, little is known about the non-H-2 antigens that cytotoxic t cells recognize on leukemia cells. In a study of leukemias induced by the radiation leukemia virus (RadLV) we have defined individually specific as well as crossreacting cell surface antigenic systems recognized by cytotoxic t cells. Questions asked in our current proposal are concerned with the relationship of these antigens to MuLV, the immunogenetics of their recognition, the heterogeneity of the T cell response, the relationship between T cell cytotoxicity in vitro and transplantation resistance in vivo, and the genetic origin of these antigens.
| Uemura, N; Salgia, R; Li, J L et al. (1997) The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins. Leukemia 11:376-85 |
| Morishita, H; Shiku, H; Horibe, K et al. (1986) Cell surface antigens of murine leukemias induced by radiation leukemia virus. Recognition of individually distinct cell surface antigens by cytotoxic T cells on leukemias expressing crossreactive transplantation antigens. J Exp Med 163:452-7 |
