Recently our laboratory, as well as others, have been studying the non-water proton NMR signals of normal and malignant tissue. In many cases larger and more definitive differences are seen in the relaxation parameters of non-water resonances, arising largely from lipid components of tissue, making characterization of malignancy more reliable. We have been able to observe aliphatic proton resonances in all types of tissue and plasma studied and have begun the correlation of their NMR relaxation parameters with malignancy. It is the overall goal of the studies proposed in this application to further characterize the NMR properties of the non-water resonances of tumors and normal tissue and define certain aspects of both the biological and biophysical mechanism responsible for the unique features of these resonances in malignancy. The data from these studies will be used to test the hypotheses that: 1) the NMR signal and its relaxation parameters arising from resolvable aliphatic resonances is a more sensitive and specific indicator of malignancy than are the composite proton resonance or the water resonance itself; and 2) that an understanding of certain aspects of the mechanism which produces differences in these properties of the aliphatic resonance will be of value to the classification of stages of malignancy and its regression as well as, perhaps, offering new understanding of certain biophysical and biochemical aspects of the disease process itself.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA036276-05
Application #
3173829
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1984-01-01
Project End
1990-02-28
Budget Start
1988-03-01
Budget End
1989-02-28
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
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McDonagh, J; Fossel, E T; Kradin, R L et al. (1992) Effects of tumor necrosis factor-alpha on peroxidation of plasma lipoprotein lipids in experimental animals and patients. Blood 80:3217-26
Fossel, E T; Fletcher, J G; McDonagh, J et al. (1991) Selective cytotoxicity of low-density lipoprotein to helper T cells of cutaneous T-cell lymphoma after photoperoxidation with 8-methoxypsoralen. J Natl Cancer Inst 83:1316-21
Fossel, E T; Hall, F M; McDonagh, J (1991) C-13 NMR spectroscopy of plasma reduces interference of hypertriglyceridemia in the H-1 NMR detection of malignancy. Application in patients with breast lesions. Breast Cancer Res Treat 18:99-110
Fossel, E T (1991) The NMR blood test for cancer: current status. Cancer Cells 3:173-82
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Fossel, E T; Carr, J M; McDonagh, J (1986) Detection of malignant tumors. Water-suppressed proton nuclear magnetic resonance spectroscopy of plasma. N Engl J Med 315:1369-76