This proposal is for a case-control study of multiple myeloma in Los Angeles County. The case-group will include 440 cases, 340 whites and 100 blacks, of multiple myeloma identified by the Los Angeles County/USC Cancer Surveillance Program and interviewed by telephone over a five-year period. Controls will be neighborhood controls from the residence of the case at diagnosis who are matched to the case on date of birth (+5 years), sex, and race. The major hypothesis to be tested is that the etiology of multiple myeloma is related to chronic antigenic stimulation especially in conjunction with underlying immune abnormality, either genetically or environmentally determined. The following major subject areas are addressed by the questionnaire: occupational exposures, radiation exposure, hormonal status, medical history, family medical history. We plan to compare risk factors in men and women and in blacks and whites and by class of immunoglobulin (IgG or IgA) secreted by the malignant cells.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA036388-05
Application #
3173961
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1985-05-01
Project End
1991-04-30
Budget Start
1989-05-01
Budget End
1991-04-30
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
Costas, Laura; Lambert, Brice H; Birmann, Brenda M et al. (2016) A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium. Cancer Epidemiol Biomarkers Prev 25:217-21
Nuyujukian, Daniel S; Voutsinas, Jenna; Bernstein, Leslie et al. (2014) Medication use and multiple myeloma risk in Los Angeles County. Cancer Causes Control 25:1233-7
Wang, Sophia S; Voutsinas, Jenna; Chang, Ellen T et al. (2013) Anthropometric, behavioral, and female reproductive factors and risk of multiple myeloma: a pooled analysis. Cancer Causes Control 24:1279-89