This proposal is for a case-control study of multiple myeloma in Los Angeles County. The case-group will include 440 cases, 340 whites and 100 blacks, of multiple myeloma identified by the Los Angeles County/USC Cancer Surveillance Program and interviewed by telephone over a five-year period. Controls will be neighborhood controls from the residence of the case at diagnosis who are matched to the case on date of birth (+5 years), sex, and race. The major hypothesis to be tested is that the etiology of multiple myeloma is related to chronic antigenic stimulation especially in conjunction with underlying immune abnormality, either genetically or environmentally determined. The following major subject areas are addressed by the questionnaire: occupational exposures, radiation exposure, hormonal status, medical history, family medical history. We plan to compare risk factors in men and women and in blacks and whites and by class of immunoglobulin (IgG or IgA) secreted by the malignant cells.
| Costas, Laura; Lambert, Brice H; Birmann, Brenda M et al. (2016) A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium. Cancer Epidemiol Biomarkers Prev 25:217-21 |
| Nuyujukian, Daniel S; Voutsinas, Jenna; Bernstein, Leslie et al. (2014) Medication use and multiple myeloma risk in Los Angeles County. Cancer Causes Control 25:1233-7 |
| Wang, Sophia S; Voutsinas, Jenna; Chang, Ellen T et al. (2013) Anthropometric, behavioral, and female reproductive factors and risk of multiple myeloma: a pooled analysis. Cancer Causes Control 24:1279-89 |
