Our goal is to explore a central mechanism by which cancer may arise from irradiation and other causes. In this scheme cancer results from an augmented or inappropriate expression of normal cellular genes (oncogenes) brought on by chemicals, radiation, viruses or aging. Some of these cellular cancer genes have been identified and characterized in retroviruses and others have been isolated by the DNA mediated 3T3 cell transformation technique. Highly specific molecularly cloned probes have been constructed that are now available for measuring expression of these oncogenes at the DNA and RNA level. By studying radiation and chemical induced leukemias in RF/Un mice and mammary tumors in BALB/cfC3H, we plan to address 7 unanswered questions: (1) Do radiation-induced neoplasms contain activated oncogenes?; (2) Are radiation-induced oncogenes related to known viral or cellular oncogenes?; (3) Are radiation-induced oncogenes the same in neoplasms from different target tissues?; (4) Do different carcinogens (chemical, viral, radiation) induce the same oncogenes in a given target tissue?; (5) At what point in the neoplastic progression are the oncogenes expressed?; (6) Does radiation induce homologous oncogenes in different species?; and (7) What is the mechanism of irradiation induced activation of oncogenes?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA036493-04
Application #
3174109
Study Section
Radiation Study Section (RAD)
Project Start
1983-12-01
Project End
1988-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
Schools of Medicine
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618