In 1982 the structure of fredericamycin was deciphered. While fredericamycin exhibits antibiotic properties, it has gained greatest attention for its in vitro and in vivo activity against a variety of anticancer screens and is regarded as a possible candidate for clinical trials. The objectives of this project are 1) to effect an expeditious synthesis of fredericamycin which can generate practical quantities of the material; 2) to utilize this synthesis to prepare analogs of fredericamycin selected to probe structure-activity relationships responsible for fredericamycin's biological activity and 3) to use the synthesis of fredericamycin as a vehicle for the further examination of the scope and limitations of lateral metalation as a general synthetic method for the preparation of pharmaceuticals and other organic materials.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037054-02
Application #
3174720
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1984-03-01
Project End
1987-02-28
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Boston College
Department
Type
Schools of Arts and Sciences
DUNS #
045896339
City
Chestnut Hill
State
MA
Country
United States
Zip Code